{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T13:33:08Z","timestamp":1762176788528,"version":"3.40.5"},"reference-count":24,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2014,12,2]],"date-time":"2014-12-02T00:00:00Z","timestamp":1417478400000},"content-version":"unspecified","delay-in-days":761,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Neurol. Sci."],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:sec id=\"S0317167100015651_abs1\"><jats:title>Background:<\/jats:title><jats:p>Chronic migraine is a significant cause of disability world-wide and occipital region stimulation (OS) has been proposed to treat it. While participating in an industry-sponsored pilot trial of OS, we aimed to collect data regarding our surgical complications and long term usage of OS in our chronic migraine patients.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100015651_abs2\"><jats:title>Methods:<\/jats:title><jats:p>Ten patients (8 female, median age 46.5 years) were enrolled based on criteria established by the sponsoring company, screened in the headache clinic, and followed for a median of 33 months. We did not access data collected by industry for this report and instead collected our own data prospectively, including predominant location of headache, location of paresthesia evoked by OS, and complications.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100015651_abs3\"><jats:title>Results:<\/jats:title><jats:p>Adverse events included three possible early infections requiring antibiotics but not hardware removal, one late implantable pulse generator erosion requiring removal, one generator malfunction requiring revision, and loss of paresthetic coverage requiring four revisions in four patients. Two patients experienced new symptoms requiring psychiatric intervention. Five patients had no benefit and have been explanted. Of those who remain using their device, the proportion of their pre-operative pain located in the occipital region was 0.62 \u00b1 0.14, whereas in those patients who have been explanted, the proportion was 0.31 \u00b1 0.18 (t = 3.15, p=0.01).<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100015651_abs4\"><jats:title>Conclusions:<\/jats:title><jats:p>Complication rates with OS are higher than those seen with other stimulation techniques, despite identical hardware and similar surgery. The location of migraine pain did predict outcome, and suggests that only those with primarily occipital region headache are candidates for this therapy.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0317167100015651","type":"journal-article","created":{"date-parts":[[2014,12,12]],"date-time":"2014-12-12T15:01:57Z","timestamp":1418396517000},"page":"807-812","source":"Crossref","is-referenced-by-count":10,"title":["Occipital Stimulation for Chronic Migraine: Patient Selection and Complications"],"prefix":"10.1017","volume":"39","author":[{"given":"Zelma H. 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