{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T12:14:31Z","timestamp":1774440871533,"version":"3.50.1"},"reference-count":15,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2014,9,23]],"date-time":"2014-09-23T00:00:00Z","timestamp":1411430400000},"content-version":"unspecified","delay-in-days":326,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Neurol. Sci."],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:sec id=\"S0317167100015948_abs1\"><jats:title>Background:<\/jats:title><jats:p>Meningiomas account for approximately 24-30% of primary intracranial neoplasms. Histopathologic grade and degree of resection are two major prognostic factors. The aim of this study was to determine the factors associated with the prognosis of meningioma.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100015948_abs2\"><jats:title>Methods:<\/jats:title><jats:p>We used immunohistochemistry to analyze the expression levels of Vav3, SPARC, p-Akt, cyclin D1, and Ki-67 in 287 meningiomas of all grades.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100015948_abs3\"><jats:title>Results:<\/jats:title><jats:p>The expression of Vav3, SPARC, p-Akt, cyclin D1, and Ki- 67 significantly increased with meningioma grade (p&lt;0.01), and was higher in brain-invasive meningiomas compared to non-invasive meningiomas (WHO grade I) (p&lt;0.05). Furthermore, the expression of Vav3, p-Akt, and Ki-67 was higher in recurrent meningiomas compared to non-recurrent meningiomas (WHO grade I) (p&lt;0.05).<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100015948_abs4\"><jats:title>Conclusion:<\/jats:title><jats:p>The expression of Vav3, SPARC, p-Akt, cyclin D1, and Ki-67 in meningiomas appears to correlate with meningioma invasiveness, aggressiveness, and recurrence.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0317167100015948","type":"journal-article","created":{"date-parts":[[2014,12,12]],"date-time":"2014-12-12T14:56:03Z","timestamp":1418396163000},"page":"814-818","source":"Crossref","is-referenced-by-count":4,"title":["SPARC and Vav3 Expression in Meningioma: Factors Related to Prognosis"],"prefix":"10.1017","volume":"40","author":[{"given":"Jie","family":"Jiang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuejia","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengjun","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiguang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiping","family":"Qi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2014,9,23]]},"reference":[{"key":"S0317167100015948_ref001","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000188281.91351.B9"},{"key":"S0317167100015948_ref002","doi-asserted-by":"publisher","DOI":"10.1007\/s004150200005"},{"key":"S0317167100015948_ref012","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0463.2009.02516.x"},{"key":"S0317167100015948_ref015","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-8-158"},{"key":"S0317167100015948_ref010","doi-asserted-by":"publisher","DOI":"10.1007\/s10585-007-9126-2"},{"key":"S0317167100015948_ref011","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.2006.00761.x"},{"key":"S0317167100015948_ref006","doi-asserted-by":"publisher","DOI":"10.1210\/me.2006-0048"},{"key":"S0317167100015948_ref005","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-008-9278-x"},{"key":"S0317167100015948_ref004","first-page":"237","article-title":"SPARC: A potential diagnostic marker of invasive meningiomas","volume":"5","author":"Rempel","year":"1999","journal-title":"Clin Cancer Res"},{"key":"S0317167100015948_ref003","first-page":"164","volume-title":"World Health Organization Classification of Tumours of the Central Nervous System","author":"Perry","year":"2007"},{"key":"S0317167100015948_ref013","doi-asserted-by":"publisher","DOI":"10.3892\/ijo_00000197"},{"key":"S0317167100015948_ref014","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-2550"},{"key":"S0317167100015948_ref009","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2006.04.001"},{"key":"S0317167100015948_ref008","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1789.2007.00750.x"},{"key":"S0317167100015948_ref007","first-page":"1168","article-title":"Immunohistochemical demonstration of Phospho-Akt in High Gleason Grade Prostate Cancer","volume":"8","author":"Malik","year":"2002","journal-title":"Clin Cancer Res"}],"container-title":["Canadian Journal of Neurological Sciences \/ Journal Canadien des Sciences Neurologiques"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0317167100015948","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T19:23:24Z","timestamp":1556047404000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0317167100015948\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["S0317167100015948"],"URL":"https:\/\/doi.org\/10.1017\/s0317167100015948","relation":{},"ISSN":["0317-1671","2057-0155"],"issn-type":[{"value":"0317-1671","type":"print"},{"value":"2057-0155","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11]]}}}