{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:42:15Z","timestamp":1787168535306,"version":"build-2736575974"},"reference-count":27,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2014,9,23]],"date-time":"2014-09-23T00:00:00Z","timestamp":1411430400000},"content-version":"unspecified","delay-in-days":326,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Neurol. Sci."],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:sec id=\"S0317167100015973_abs1\"><jats:title>Background:<\/jats:title><jats:p>Neuromyelitis optica (NMO) and multiple sclerosis (MS) are chronic neuro-inflammatory diseases believed to arise from complex interactions between environmental and genetic factors. Recently, single nucleotide polymorphisms (SNPs) in interleukin (IL)-2 and -7 receptor alpha genes have been identified as novel susceptibility alleles for MS in genome-wide association studies. However, similar research on NMO is limited. We aimed to investigate the association of<jats:italic>IL2RA<\/jats:italic>SNPs rs2104286 and rs12722489 and<jats:italic>IL7RA<\/jats:italic>SNP rs6897932 with Southern Han Chinese NMO and MS patients.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100015973_abs2\"><jats:title>Methods:<\/jats:title><jats:p>Frequencies of the three SNPs were examined in Southern Han Chinese mS cases (n=78), NMS cases (n=67) and controls (n=133) using sequencing-based typing.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100015973_abs3\"><jats:title>Results:<\/jats:title><jats:p>The rs2104286<jats:sup>G<\/jats:sup>frequency in the<jats:italic>IL2RA<\/jats:italic>gene was significantly higher in NMO patients than in controls (<jats:italic>p<\/jats:italic><jats:sup>uncorr<\/jats:sup>=0.013,<jats:italic>p<\/jats:italic><jats:sup>corr<\/jats:sup>=0.026, OR:1.942, 95%CI:1.146-3.291).<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100015973_abs4\"><jats:title>Conclusion:<\/jats:title><jats:p>The rs2104286 G allele in<jats:italic>IL2RA<\/jats:italic>is present at higher frequencies in NMO patients than in healthy controls within a Southern Han Chinese population.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0317167100015973","type":"journal-article","created":{"date-parts":[[2014,12,12]],"date-time":"2014-12-12T14:56:03Z","timestamp":1418396163000},"page":"832-835","source":"Crossref","is-referenced-by-count":14,"title":["IL2RA Allele Increases Risk of Neuromyelitis Optica in Southern Han Chinese"],"prefix":"10.1017","volume":"40","author":[{"given":"Yongqiang","family":"Dai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaonan","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuge","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengqi","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuhua","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueqiang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2014,9,23]]},"reference":[{"key":"S0317167100015973_ref022","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-008-1070-4"},{"key":"S0317167100015973_ref018","doi-asserted-by":"publisher","DOI":"10.1038\/nri1435"},{"key":"S0317167100015973_ref015","doi-asserted-by":"publisher","DOI":"10.1038\/ng2103"},{"key":"S0317167100015973_ref012","first-page":"143","article-title":"CTLA4 in multiple sclerosis","volume":"184","author":"Rasmussen","year":"2001","journal-title":"Lack of genetic association in a european Caucasian population but evidence of interaction with HLA-DR2 among Shanghai Chinese. 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