{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T20:45:45Z","timestamp":1786999545166,"version":"build-2736575974"},"reference-count":33,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2014,9,23]],"date-time":"2014-09-23T00:00:00Z","timestamp":1411430400000},"content-version":"unspecified","delay-in-days":206,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Neurol. Sci."],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:sec id=\"S0317167100016668_abs1\">\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>We conducted a retrospective chart review of 53 patients diagnosed with sporadic Inclusion Body Myositis (sIBM) who have been followed at the McMaster Neuromuscular Clinic since 1996.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0317167100016668_abs2\">\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>We reviewed patient medical histories in order to compare our findings with similar cohorts, and analyzed quantitative strength data to determine functionality in guiding decisions related to gait assistive devices.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0317167100016668_abs3\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Patient information was acquired through retrospective clinic chart review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0317167100016668_abs4\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Our study found knee extension strength decreased significantly as patients transitioned to using more supportive gait assistive devices (P &lt; 0.05). A decline to below 30 Nm was particularly indicative of the need for a preliminary device (i.e. cane)(P &lt; 0.05). Falls and fear of falling poses a significant threat to patient physical well-being. The prevalence of dysphagia increased as patients required more supportive gait devices, and finally a significant negative correlation was found between time after onset and creatine kinase (CK) levels (P &lt; 0.01).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0317167100016668_abs5\">\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This study supports that knee extension strength may be a useful tool in advising patients concerning ambulatory assistance. Further investigations concerning gait assistive device use and patient history of falling would be beneficial in preventing future falls and improving long-term patient outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s0317167100016668","type":"journal-article","created":{"date-parts":[[2014,12,2]],"date-time":"2014-12-02T12:13:12Z","timestamp":1417522392000},"page":"253-259","source":"Crossref","is-referenced-by-count":8,"title":["Functional Impairment in Patients with Sporadic Inclusion Body Myositis"],"prefix":"10.1017","volume":"41","author":[{"given":"Heather V.","family":"Dunlap","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren G.","family":"MacNeil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark 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