{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T22:00:11Z","timestamp":1761948011792},"reference-count":19,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2014,10,20]],"date-time":"2014-10-20T00:00:00Z","timestamp":1413763200000},"content-version":"unspecified","delay-in-days":111,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Neurol. Sci."],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:sec id=\"S0317167100018485_abs1\"><jats:title>Context:<\/jats:title><jats:p>Since the beginning of the new millennium, prevalence of syphilis has re-increased and is once again, a major public health problem. Neurosyphilis is the extension of syphilitic infection to the nervous system. It is considered by many as a cause of reversible dementia, when treated early. However, scarce data exist on the evolution of cognitive and behavioral impairments in patients affected by tertiary neurosyphilis.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100018485_abs2\"><jats:title>Objectives:<\/jats:title><jats:p>The aim of this study was to explore the cognitive and behavioral changes in a cohort of patients diagnosed with neurosyphilis.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100018485_abs3\"><jats:title>Design:<\/jats:title><jats:p>A retrospective study based on systematized chart review between 2000 and 2012 in a large neurological tertiary care facility.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100018485_abs4\"><jats:title>Outcome measure:<\/jats:title><jats:p>Clinical evaluations by treating physicians.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100018485_abs5\"><jats:title>Results:<\/jats:title><jats:p>Eighteen patients were identified with tertiary neurosyphilis. Out of this group, only two had systematic neuropsychological follow-up despite physician reports of significant and persistent cognitive and psychiatric changes. For these two cases, only slight improvements were noted in memory and executive skills while improvements in attention were marked. None of our patients had previous psychiatric history yet a large proportion developed symptoms after the infection.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100018485_abs6\"><jats:title>Conclusion:<\/jats:title><jats:p>Although neurosyphilis is traditionally considered a reversible form of dementia, we found limited support for this claim in our two patients with close follow-up. Quality data on the cognitive and psychiatric changes in the rest of our cohort was dramatically lacking, and this could not be explained by absence of symptoms at presentation. Given the recrudescence of syphilis, we propose a systematic approach to the evaluation and follow-up of this disorder.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0317167100018485","type":"journal-article","created":{"date-parts":[[2014,12,2]],"date-time":"2014-12-02T16:25:29Z","timestamp":1417537529000},"page":"452-458","source":"Crossref","is-referenced-by-count":14,"title":["Neurocognitive Changes in Tertiary Neurosyphilis: A Retrospective Chart Review"],"prefix":"10.1017","volume":"41","author":[{"given":"Philippe","family":"Beauchemin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Robert","family":"Laforce","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2014,10,20]]},"reference":[{"key":"S0317167100018485_ref019","doi-asserted-by":"publisher","DOI":"10.1176\/appi.neuropsych.12.2.246"},{"key":"S0317167100018485_ref018","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2009.10.3.310"},{"key":"S0317167100018485_ref011","first-page":"1","article-title":"Case definitions for public health surveillance","volume":"39","author":"Wharton","year":"1990","journal-title":"MMWR Recomm Rep"},{"key":"S0317167100018485_ref008","doi-asserted-by":"publisher","DOI":"10.1007\/s11908-009-0019-1"},{"key":"S0317167100018485_ref003","first-page":"1","article-title":"Centers for Disease Control and Prevention. 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Autopsy studies in syphilis"},{"key":"S0317167100018485_ref016","first-page":"703","article-title":"Neurosyphilis in HIV-positive and HIV-negative patients: neuroimaging findings","volume":"16","author":"Brightbill","year":"1995","journal-title":"AJNR Am J Neuroradiol"},{"key":"S0317167100018485_ref009","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-109-11-855"},{"key":"S0317167100018485_ref004","volume-title":"Syphilis infectueuse au Qu\u00e9bec. Appel \u00e0 la vigilance","year":"2010"}],"container-title":["Canadian Journal of Neurological Sciences \/ Journal Canadien des Sciences Neurologiques"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0317167100018485","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,22]],"date-time":"2019-04-22T19:04:04Z","timestamp":1555959844000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0317167100018485\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["S0317167100018485"],"URL":"https:\/\/doi.org\/10.1017\/s0317167100018485","relation":{},"ISSN":["0317-1671","2057-0155"],"issn-type":[{"value":"0317-1671","type":"print"},{"value":"2057-0155","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7]]}}}