{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T07:07:10Z","timestamp":1761808030954},"reference-count":16,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2015,9,18]],"date-time":"2015-09-18T00:00:00Z","timestamp":1442534400000},"content-version":"unspecified","delay-in-days":14839,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. j. neurol. sci."],"published-print":{"date-parts":[[1975,2]]},"abstract":"<jats:title>SUMMARY:<\/jats:title><jats:p>Thirty-nine patients with a variety of diseases, including essential tremor, Parkinson\u07e3s Disease, olivopontocerebellar degeneration, ataxia telangiectasia, and cervical cord injury with action tremor, were evaluated for the effect of one ounce of absolute alcohol ingestion. Tremor significantly subsided in 61.9% of E.T.; 46.6% of P.D.; one patient with A.T.; and one patient with C6 lesion. The tremor became worse in one patient with O.P.C.D. Twenty of these patients were treated with propranolol, an average dose of 92 mgm. per day, and re-evaluated three to six months later. All those who improved on alcohol improved on propranolol and the one whose tremor accentuated with alcohol had a similar response to propranolol. It is concluded that the tremorilytic effect of alcohol is neither specific for, nor limited to, essential tremor and is of no value in differentiating various neurological disorders which manifest as action tremor. It is recommended that one ounce of absolute alcohol by mouth be used as an office procedure to predict the response of patients\u07e3 tremor to propranolol.<\/jats:p>","DOI":"10.1017\/s0317167100019958","type":"journal-article","created":{"date-parts":[[2016,7,28]],"date-time":"2016-07-28T11:31:11Z","timestamp":1469705471000},"page":"31-35","source":"Crossref","is-referenced-by-count":42,"title":["Relative Efficacy of Alcohol and Propranolol in Action Tremor"],"prefix":"10.1017","volume":"2","author":[{"given":"A.H.","family":"Rajput","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Jamieson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Hirsh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Quraishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2015,9,18]]},"reference":[{"key":"S0317167100019958_ref012","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(65)92279-8"},{"key":"S0317167100019958_ref003","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.35.3.365"},{"key":"S0317167100019958_ref005","first-page":"98","article-title":"Propranolol in essential tremor","volume":"2","author":"Gilligan","year":"1972","journal-title":"Lancet"},{"key":"S0317167100019958_ref010","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.36.4.618"},{"key":"S0317167100019958_ref001","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(71)90183-3"},{"key":"S0317167100019958_ref004","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1973.tb01280.x"},{"key":"S0317167100019958_ref008","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1001\/jama.1973.03220390056018","article-title":"Current status of Propranolol Hydrochloride (Inderal)","volume":"225","author":"Kosman","year":"1973","journal-title":"Journal of the American Medical Association"},{"key":"S0317167100019958_ref013","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(72)90431-X"},{"key":"S0317167100019958_ref009","volume-title":"\u201cTremor\u201d in Handbook of Clinical Neurology","author":"Marshall","year":"1968"},{"key":"S0317167100019958_ref011","first-page":"984","article-title":"Treatment of essential tremor with propranolol","volume":"107","author":"Murray","year":"1972","journal-title":"Canadian Medical Association Journal"},{"key":"S0317167100019958_ref007","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(72)90817-3"},{"key":"S0317167100019958_ref015","volume-title":"\u201cEthyl alcohol\u201d in The Pharmacological Basis of Therapeutics","author":"Ritchie","year":"1965"},{"key":"S0317167100019958_ref006","first-page":"382","article-title":"The effect of alcohol on essential tremor","volume":"24","author":"Growdon","year":"1974","journal-title":"Neurology"},{"key":"S0317167100019958_ref002","first-page":"876","article-title":"The nature of essential tremor","volume":"109","author":"Ashenhurst","year":"1973","journal-title":"Canadian Medical Association Journal"},{"key":"S0317167100019958_ref014","first-page":"1018","article-title":"Specificity of tremorilytic effects of alcohol and propranolol","volume":"21","author":"Rajput","year":"1973","journal-title":"Clinical Research"},{"key":"S0317167100019958_ref016","first-page":"96","article-title":"The control of essential tremor by propranolol","author":"Winkler","year":"1971","journal-title":"Transactions of the American Neurological Association"}],"container-title":["Canadian Journal of Neurological Sciences \/ Journal Canadien des Sciences Neurologiques"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0317167100019958","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T20:12:20Z","timestamp":1559160740000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0317167100019958\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1975,2]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1975,2]]}},"alternative-id":["S0317167100019958"],"URL":"https:\/\/doi.org\/10.1017\/s0317167100019958","relation":{},"ISSN":["0317-1671","2057-0155"],"issn-type":[{"value":"0317-1671","type":"print"},{"value":"2057-0155","type":"electronic"}],"subject":[],"published":{"date-parts":[[1975,2]]}}}