{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T12:44:25Z","timestamp":1718369065266},"reference-count":21,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2015,9,18]],"date-time":"2015-09-18T00:00:00Z","timestamp":1442534400000},"content-version":"unspecified","delay-in-days":6622,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. j. neurol. sci."],"published-print":{"date-parts":[[1997,8]]},"abstract":"<jats:title>ABSTRACT:<\/jats:title><jats:sec id=\"S0317167100021892_abs1\"><jats:title>Background:<\/jats:title><jats:p>The most common cause of acromegaly is excess of growth hormone (GH) secretion.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100021892_abs2\"><jats:title>Methods:<\/jats:title><jats:p>We report a 42-year-old male patient, who had become acromegalic over the past 5 years. There were no visual changes or change in sexual function, no gynaecomastia or galactorrhoea. Both CT and MRI scans showed a large mass measuring 2.5 x 2.5 x 3.5 cm, originating from the sella turcica and extending into and totally filling up the sphenoid sinus with diffusely invasive features.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100021892_abs3\"><jats:title>Results:<\/jats:title><jats:p>Basal serum GH level was within normal range, but insulin-like growth factor 1 (IGF-1) was elevated with slightly increased prolactin (PRL) and impaired GH secretory regulation as well. A pituitary adenoma was partially removed through transsphenoidal microsurgery. Pathology confirmed a mammo-somatotrophic adenoma but immunocytochemistry study of the tumour showed only positivity for PRL but not GH.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100021892_abs4\"><jats:title>Conclusions:<\/jats:title><jats:p>When acromegaly occurs without GH level elevation, one should pay attention that: 1) IGF-1 might be the cause of the clinical feature of acromegaly; 2) The tumour might undergo morphological transformation; and 3) Hyperinsulinemia or GH receptor antibody formation could also be the cause of the acromegalic appearance.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0317167100021892","type":"journal-article","created":{"date-parts":[[2016,2,17]],"date-time":"2016-02-17T09:26:22Z","timestamp":1455701182000},"page":"250-253","source":"Crossref","is-referenced-by-count":2,"title":["Acromegaly with Normal Basal Growth Hormone Levels"],"prefix":"10.1017","volume":"24","member":"56","published-online":{"date-parts":[[2015,9,18]]},"reference":[{"key":"S0317167100021892_ref011","doi-asserted-by":"publisher","DOI":"10.1210\/endo-123-6-2827"},{"key":"S0317167100021892_ref018","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-48-3-495"},{"key":"S0317167100021892_ref012","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1530\/acta.0.1220745","article-title":"Growth hormone and somatostatin gene expression in pituitary adenomas with active acromegaly and minimal plasma growth hormone elevation","volume":"122","author":"Pagesy","year":"1990","journal-title":"Acta 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sup\u00e9rieures, inf\u00e9rieures et c\u00e9phalique","author":"Marie","year":"1886","journal-title":"Rev Med"},{"key":"S0317167100021892_ref006","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1003342"},{"key":"S0317167100021892_ref005","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-81-6-781"},{"key":"S0317167100021892_ref015","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(93)90056-M"},{"key":"S0317167100021892_ref014","first-page":"243","volume-title":"Molecular and Clinical Advances in Pituitary Disorders: Proceedings of the 3rd International Pituitary Congress","author":"Ferreira","year":"1993"},{"key":"S0317167100021892_ref021","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-59-2-212"},{"key":"S0317167100021892_ref016","first-page":"605","article-title":"Human growth hormone and prolactin secreting pituitary adenomas analyzed by in situ hybridization","volume":"134","author":"Lloyd","year":"1989","journal-title":"Am J 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Sciences Neurologiques"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0317167100021892","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T11:58:01Z","timestamp":1718366281000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0317167100021892\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,8]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1997,8]]}},"alternative-id":["S0317167100021892"],"URL":"https:\/\/doi.org\/10.1017\/s0317167100021892","relation":{},"ISSN":["0317-1671","2057-0155"],"issn-type":[{"value":"0317-1671","type":"print"},{"value":"2057-0155","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,8]]}}}