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The five brains were analysed by quantitative morphometry to determine the degree of neurofibrillary tangle formation in mesial temporal neurons. The density of tangle-bearing nerve cells in the four unimproved cases was markedly greater than in age-matched control brains from nineteen normal subjects, and fell in the same range as that of eight dements with neuropathologically confirmed Alzheimer's disease. The density of the one who recovered was within normal limits.<\/jats:p><jats:p>The duration of dementia before shunting, and the total duration of dementia in these five patients rank in the same order as their degree of neurofibrillary formation. Furthermore, a positive linear correlation exists between the Tangle Indices and the total duration of dementia. The data suggest that early diagnosis may improve the chances of reversing the dementia of normal pressure hydrocephalus before histological alterations prove too severe.<\/jats:p>","DOI":"10.1017\/s0317167100025348","type":"journal-article","created":{"date-parts":[[2016,7,28]],"date-time":"2016-07-28T11:32:11Z","timestamp":1469705531000},"page":"227-235","source":"Crossref","is-referenced-by-count":18,"title":["Neurofibrillary Tangles in the Dementia of \u201cNormal Pressure\u201d Hydrocephalus"],"prefix":"10.1017","volume":"3","author":[{"given":"Melvyn J.","family":"Ball","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2015,9,18]]},"reference":[{"key":"S0317167100025348_ref011","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.15.8.774"},{"key":"S0317167100025348_ref018","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1976.03260310024015"},{"key":"S0317167100025348_ref029","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1976.03260310048025"},{"key":"S0317167100025348_ref010","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1974.00490400076009"},{"key":"S0317167100025348_ref026","first-page":"1058","article-title":"Alzheimer\u2019s disease with abnormal cerebrospinal fluid flow","volume":"4","author":"Sohn","journal-title":"Neurology"},{"key":"S0317167100025348_ref019","first-page":"89","article-title":"Presenile dementia and hydrocephalus","author":"J\u00e4rpe","year":"1970","journal-title":"Acta Neurologica Scandinavia 46"},{"key":"S0317167100025348_ref008","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(73)90040-3"},{"key":"S0317167100025348_ref030","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.23.3.234"},{"key":"S0317167100025348_ref033","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.23.7.706"},{"key":"S0317167100025348_ref001","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196507152730301"},{"key":"S0317167100025348_ref002","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0033-8389(22)00940-X","article-title":"Radiologic investigations of normal pressure hydrocephalus","volume":"12","author":"Adapon","year":"1974","journal-title":"Radiology Clinics of North America"},{"key":"S0317167100025348_ref017","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-196804000-00001"},{"key":"S0317167100025348_ref005","doi-asserted-by":"publisher","DOI":"10.1007\/BF01402168"},{"key":"S0317167100025348_ref031","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(70)90063-8"},{"key":"S0317167100025348_ref027","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1974.41.4.0463"},{"key":"S0317167100025348_ref014","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(74)91496-2"},{"key":"S0317167100025348_ref003","first-page":"146","article-title":"Uber eine eigenar-tige Erkrankung der Hirnrinde","volume":"64","author":"Alzheimer","year":"1907","journal-title":"Allgemein Zeitschrift fiir Psychiatrie"},{"key":"S0317167100025348_ref004","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.1976.tb00513.x"},{"key":"S0317167100025348_ref007","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1973.00490290039003"},{"key":"S0317167100025348_ref012","doi-asserted-by":"publisher","DOI":"10.1007\/BF00685305"},{"key":"S0317167100025348_ref013","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(68)90054-3"},{"key":"S0317167100025348_ref015","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(65)90016-X"},{"key":"S0317167100025348_ref016","doi-asserted-by":"publisher","DOI":"10.1148\/95.1.109"},{"key":"S0317167100025348_ref025","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1964.00460190044004"},{"key":"S0317167100025348_ref032","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711060305"},{"key":"S0317167100025348_ref028","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.26.3.241"},{"key":"S0317167100025348_ref006","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.114.512.797"},{"key":"S0317167100025348_ref024","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1969.31.3.0279"},{"key":"S0317167100025348_ref022","first-page":"529","article-title":"Alzheimer\u2019s disease","author":"McMenemey","year":"1971","journal-title":"Greenfields\u2019s Neuropathology. 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