{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T17:17:26Z","timestamp":1761844646240},"reference-count":17,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2015,9,18]],"date-time":"2015-09-18T00:00:00Z","timestamp":1442534400000},"content-version":"unspecified","delay-in-days":10367,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. j. neurol. sci."],"published-print":{"date-parts":[[1987,5]]},"abstract":"<jats:title>Abstract:<\/jats:title><jats:p>A young man developed virologically proved hydrophobic rabies three months after being scratched on the cheek by a bat in Northern Alberta. He became comatose after 8 days and died 5 weeks after vigorous therapy with immune globulin, interferon and Vidarabine, and excellent maintenance of oxygenation. Electroencephalographic deterioration was gradual. At postmortem examination, the brain showed widespread loss of nerve cells, mild diffuse inflammatory changes and no Negri bodies. The lesions of massive laminar necrosis of the cerebral cortex, total loss of Purkinje cells with preservation of the granule cell layer, and severe softening of the amygdala are attributed to direct viral action rather than to anoxia or brain swelling with respirator brain.<\/jats:p>","DOI":"10.1017\/s0317167100026329","type":"journal-article","created":{"date-parts":[[2016,7,28]],"date-time":"2016-07-28T11:38:35Z","timestamp":1469705915000},"page":"162-165","source":"Crossref","is-referenced-by-count":28,"title":["Massive Necrosis of the Brain in Rabies"],"prefix":"10.1017","volume":"14","author":[{"given":"C.L.","family":"Dolman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.M.","family":"Charlton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2015,9,18]]},"reference":[{"key":"S0317167100026329_ref004","first-page":"12","volume-title":"A biological perspective","author":"Macdonald","year":"1980"},{"key":"S0317167100026329_ref014","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/122.4.318"},{"key":"S0317167100026329_ref015","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1980.00330220027012"},{"key":"S0317167100026329_ref010","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.15.11.1023"},{"key":"S0317167100026329_ref005","first-page":"331","volume-title":"The Natural History of Rabies","author":"Bell","year":"1976"},{"key":"S0317167100026329_ref003","first-page":"49","article-title":"A suspected case of human rabies, Nova Scotia","volume":"13","author":"King","year":"1978","journal-title":"Canada Dis Weekly Rep"},{"key":"S0317167100026329_ref017","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196011242632106"},{"key":"S0317167100026329_ref002","first-page":"215","article-title":"A human case of unsuspected rabies in Saskatchewan diagnosed by virus isolation","volume":"63","author":"Dempster","year":"1972","journal-title":"Can J Pub Health"},{"key":"S0317167100026329_ref001","first-page":"49","volume":"13","year":"1978","journal-title":"A suspected case of human rabies \u2014 Nova Scotia"},{"key":"S0317167100026329_ref006","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-76-6-931"},{"key":"S0317167100026329_ref009","doi-asserted-by":"publisher","DOI":"10.1016\/0147-9571(86)90076-7"},{"key":"S0317167100026329_ref011","first-page":"236","article-title":"The pathology of rabies in the central nervous system","author":"Perl","year":"1976","journal-title":"The Natural History of Rabies"},{"key":"S0317167100026329_ref012","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(76)90427-7"},{"key":"S0317167100026329_ref013","first-page":"235","volume-title":"Handbook of Clinical Neurology","volume":"34","author":"Atanasiu","year":"1978"},{"key":"S0317167100026329_ref008","unstructured":"Webster WA , Casey GA , Charlton KM , et al. A case of human rabies in Western Canada. Can J Publ Health \u2014 in press."},{"key":"S0317167100026329_ref016","doi-asserted-by":"publisher","DOI":"10.1001\/jama.246.15.1703"},{"key":"S0317167100026329_ref007","first-page":"73","volume-title":"Laboratory Techniques in Rabies","author":"Dean","year":"1973"}],"container-title":["Canadian Journal of Neurological Sciences \/ Journal Canadien des Sciences Neurologiques"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0317167100026329","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,21]],"date-time":"2019-05-21T21:25:13Z","timestamp":1558473913000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0317167100026329\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,5]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1987,5]]}},"alternative-id":["S0317167100026329"],"URL":"https:\/\/doi.org\/10.1017\/s0317167100026329","relation":{},"ISSN":["0317-1671","2057-0155"],"issn-type":[{"value":"0317-1671","type":"print"},{"value":"2057-0155","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,5]]}}}