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The second had facial dysmorphism, severe laryngeal hypoplasia, tracheomalacia and an aberrant innominate artery that caused tracheal compression. A left superior vena cava, abnormal pulmonary lobulation, and unilateral hydronephrosis were also found at autopsy. Valproic acid has probable teratogenic potential in humans but the number of reported cases is few and the spectrum of anomalies is broad so it is not possible to delineate a definite fetal valproate syndrome.<\/jats:p>","DOI":"10.1017\/s0317167100026639","type":"journal-article","created":{"date-parts":[[2016,7,28]],"date-time":"2016-07-28T11:38:40Z","timestamp":1469705920000},"page":"290-293","source":"Crossref","is-referenced-by-count":35,"title":["Congenital Malformations Associated with Maternal Use of Valproic Acid"],"prefix":"10.1017","volume":"14","author":[{"given":"Celine","family":"Huot","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Gauthier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Lebel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Larbrisseau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2015,9,18]]},"reference":[{"key":"S0317167100026639_ref005","first-page":"438","article-title":"Valproate: A new cause of birth defects \u2014 report from Italy and follow-up from France","volume":"32","year":"1983","journal-title":"MMWR"},{"key":"S0317167100026639_ref018","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198502283120906"},{"key":"S0317167100026639_ref017","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(84)90243-7"},{"key":"S0317167100026639_ref011","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.286.6360.190"},{"key":"S0317167100026639_ref012","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)90656-6"},{"key":"S0317167100026639_ref007","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(80)80517-8"},{"key":"S0317167100026639_ref001","first-page":"105","volume-title":"Clinical and pharmacological aspects of sodium valproate (Epilim) in the treatmentofepilepsy","author":"Abdelal","year":"1976"},{"key":"S0317167100026639_ref002","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(80)91159-9"},{"key":"S0317167100026639_ref003","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420270106"},{"key":"S0317167100026639_ref008","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/S0022-3565(25)32875-2","article-title":"Valproic acid and its metabolites: placental transfer, neonatal pharmacokinetics, transfer via mother's milk and clinical status in neonates of epileptic mothers","volume":"219","author":"Nau","year":"1981","journal-title":"J Pharmacol Exp Ther"},{"key":"S0317167100026639_ref004","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(82)90908-4"},{"key":"S0317167100026639_ref006","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)91711-3"},{"key":"S0317167100026639_ref010","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(82)90141-6"},{"key":"S0317167100026639_ref013","doi-asserted-by":"publisher","DOI":"10.1177\/000992288402300611"},{"key":"S0317167100026639_ref014","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320190308"},{"key":"S0317167100026639_ref015","first-page":"291","article-title":"Possible valproate teratogenecity","volume":"42","author":"Tein","year":"1985","journal-title":"Neurol"},{"key":"S0317167100026639_ref016","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(86)80949-0"},{"key":"S0317167100026639_ref009","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(81)80429-5"}],"container-title":["Canadian Journal of Neurological Sciences \/ Journal Canadien des Sciences Neurologiques"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0317167100026639","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T07:13:16Z","timestamp":1749021196000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0317167100026639\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,8]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1987,8]]}},"alternative-id":["S0317167100026639"],"URL":"https:\/\/doi.org\/10.1017\/s0317167100026639","relation":{},"ISSN":["0317-1671","2057-0155"],"issn-type":[{"value":"0317-1671","type":"print"},{"value":"2057-0155","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,8]]}}}