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Although FAD which appears to be transmitted as an autosomal dominant trait is relatively rare, such families must be identified and carefully counselled with respect to recurrence risks for subsequent generations. In this family, there are currently 20 members of Generation IV, aged 15-37, and 9 members of Generation V, aged 1-11. The majority of these individuals appear to have a 50% risk for developing this disease.<\/jats:p>","DOI":"10.1017\/s0317167100027517","type":"journal-article","created":{"date-parts":[[2016,7,28]],"date-time":"2016-07-28T11:39:22Z","timestamp":1469705962000},"page":"142-146","source":"Crossref","is-referenced-by-count":15,"title":["Familial Alzheimer's Disease"],"prefix":"10.1017","volume":"15","author":[{"given":"A.D.","family":"Sadovnick","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Tuokko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Horton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.A.","family":"Baird","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.L.","family":"Beattie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanford M.","family":"Spiegel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2015,9,18]]},"reference":[{"key":"S0317167100027517_ref023","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320260202"},{"key":"S0317167100027517_ref019","volume-title":"Manual for the Luria-Nebraska Neuropsychological Battery","author":"Golden","year":"1980"},{"key":"S0317167100027517_ref018","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3932(68)90038-9"},{"key":"S0317167100027517_ref016","doi-asserted-by":"publisher","DOI":"10.1017\/S0714980800015919"},{"key":"S0317167100027517_ref015","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320100110"},{"key":"S0317167100027517_ref011","doi-asserted-by":"publisher","DOI":"10.1001\/archneurpsyc.1934.02250040061004"},{"key":"S0317167100027517_ref024","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320260208"},{"key":"S0317167100027517_ref009","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1979.tb02924.x"},{"key":"S0317167100027517_ref006","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1966.00470150003001"},{"key":"S0317167100027517_ref005","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8619(18)30980-0"},{"key":"S0317167100027517_ref004","doi-asserted-by":"publisher","DOI":"10.1007\/BF02864363"},{"key":"S0317167100027517_ref003","doi-asserted-by":"publisher","DOI":"10.1007\/BF02864478"},{"key":"S0317167100027517_ref002","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8619(18)30973-3"},{"key":"S0317167100027517_ref014","doi-asserted-by":"publisher","DOI":"10.1126\/science.3810168"},{"key":"S0317167100027517_ref001","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8619(18)30972-1"},{"key":"S0317167100027517_ref007","doi-asserted-by":"publisher","DOI":"10.1126\/science.2880399"},{"key":"S0317167100027517_ref012","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(81)90190-8"},{"key":"S0317167100027517_ref017","volume-title":"Manual","author":"Weschler","year":"1955"},{"key":"S0317167100027517_ref022","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.20.3.179"},{"key":"S0317167100027517_ref020","doi-asserted-by":"publisher","DOI":"10.1080\/01688638408401233"},{"key":"S0317167100027517_ref021","volume-title":"Neurosensory Centre Comprehensive Examination for Aphasia","author":"Spreen","year":"1969"},{"key":"S0317167100027517_ref013","doi-asserted-by":"publisher","DOI":"10.1016\/0197-4580(86)90071-0"},{"key":"S0317167100027517_ref008","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.37.3.359"},{"key":"S0317167100027517_ref010","first-page":"1","article-title":"Morbus Alzheimer and morbus Pick: genetic, chemical, and pathoanatomical study","author":"Sjogren","year":"1952","journal-title":"Acta Psychiatr Neurol Scand"}],"container-title":["Canadian Journal of Neurological Sciences \/ Journal Canadien des Sciences Neurologiques"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0317167100027517","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,20]],"date-time":"2019-05-20T19:50:25Z","timestamp":1558381825000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0317167100027517\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,5]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1988,5]]}},"alternative-id":["S0317167100027517"],"URL":"https:\/\/doi.org\/10.1017\/s0317167100027517","relation":{},"ISSN":["0317-1671","2057-0155"],"issn-type":[{"value":"0317-1671","type":"print"},{"value":"2057-0155","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,5]]}}}