{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T14:27:07Z","timestamp":1781188027201,"version":"3.54.1"},"reference-count":22,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2015,9,18]],"date-time":"2015-09-18T00:00:00Z","timestamp":1442534400000},"content-version":"unspecified","delay-in-days":10001,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. j. neurol. sci."],"published-print":{"date-parts":[[1988,5]]},"abstract":"<jats:title>ABSTRACT:<\/jats:title><jats:p>Wernicke disease (WD) is a complication of alcoholism and malnutrition and usually presents acutely and is characterized by disturbances of consciousness, paralysis of the external ocular muscles, and ataxia. The disease results from deficiency of vitamin B 1, or thiamine, an essential coenzyme in intermediate carbohydrate metabolism. On the other hand, Jakob-Creutzfeldt disease (J-C) results from infection with an unconventional agent with a long incubation period and is characterized by a rapidly progressive dementia and histologically by a spongiform encephalopathy associated with neuronal destruction and pronounced astrogliosis. Combination of both diseases has not been reported in the literature previously and their relationship is uncertain. We present 3 cases with this interesting association and consider their relationship.<\/jats:p>","DOI":"10.1017\/s0317167100027542","type":"journal-article","created":{"date-parts":[[2016,7,28]],"date-time":"2016-07-28T11:39:22Z","timestamp":1469705962000},"page":"156-160","source":"Crossref","is-referenced-by-count":12,"title":["Jakob-Creutzfeldt Disease Associated with Wernicke Encephalopathy"],"prefix":"10.1017","volume":"15","author":[{"given":"S.","family":"Gaytan-Garcia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.J.","family":"Gilbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.H.N.","family":"Deck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.C.E.","family":"Kaufmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2015,9,18]]},"reference":[{"key":"S0317167100027542_ref021","doi-asserted-by":"publisher","DOI":"10.1126\/science.349691"},{"key":"S0317167100027542_ref018","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197712222972503"},{"key":"S0317167100027542_ref017","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410210114"},{"key":"S0317167100027542_ref016","doi-asserted-by":"publisher","DOI":"10.1007\/BF00688148"},{"key":"S0317167100027542_ref013","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(82)90039-3"},{"key":"S0317167100027542_ref012","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(78)92663-6"},{"key":"S0317167100027542_ref011","volume-title":"The Wernicke-Korsakoff syndrome","author":"Victor","year":"1971"},{"key":"S0317167100027542_ref008","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/101.2.333"},{"key":"S0317167100027542_ref005","first-page":"943","volume":"197","author":"Gajdusek","year":"1977","journal-title":"Unconventional virus and the origin and disappearance of Kuru Science"},{"key":"S0317167100027542_ref003","doi-asserted-by":"publisher","DOI":"10.1159\/000114622"},{"key":"S0317167100027542_ref020","unstructured":"Center for Disease Control. National Nosocomial Infections study report, Annual Summary 1979: Atlanta, US Department of Health and Human Services 1982."},{"key":"S0317167100027542_ref022","first-page":"229","volume-title":"Slow Transmissible Disease of the Nervous System","volume":"1","author":"Bernoulli","year":"1979"},{"key":"S0317167100027542_ref014","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196604282741705"},{"key":"S0317167100027542_ref001","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198504183121606"},{"key":"S0317167100027542_ref004","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/103.4.885"},{"key":"S0317167100027542_ref007","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.s3-6.1.78"},{"key":"S0317167100027542_ref009","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1981.00510080035002"},{"key":"S0317167100027542_ref015","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(82)90955-2"},{"key":"S0317167100027542_ref006","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-198501000-00001"},{"key":"S0317167100027542_ref019","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0733-8619(18)31104-6","article-title":"The human spongiform encephalopathies","volume":"2","author":"Bendheim","year":"1984","journal-title":"Neurol Clinics"},{"key":"S0317167100027542_ref002","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.42.3.226"},{"key":"S0317167100027542_ref010","first-page":"54","article-title":"Wernicke encephalopathy","volume":"4","author":"Cravioto","year":"1961","journal-title":"Arch Neurol"}],"container-title":["Canadian Journal of Neurological Sciences \/ Journal Canadien des Sciences Neurologiques"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0317167100027542","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,20]],"date-time":"2019-05-20T19:50:16Z","timestamp":1558381816000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0317167100027542\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,5]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1988,5]]}},"alternative-id":["S0317167100027542"],"URL":"https:\/\/doi.org\/10.1017\/s0317167100027542","relation":{},"ISSN":["0317-1671","2057-0155"],"issn-type":[{"value":"0317-1671","type":"print"},{"value":"2057-0155","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,5]]}}}