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Eight patients (44%) had multiple cerebral infarcts and morphologically, a large number of these antedated the transplantation. In addition 4 patients had acute focal ischemic changes which occurred after transplantation. Intracranial hemorrhage was noted in 5 patients (28%), including one case of fatal intracerebral hemorrhage following an acute hypertensive episode after the transplantation. While systemic infection was common (10 patients), there were only 5 cases of intracranial infection; including 3 cases of cytomegalovirus infection, one of candidiasis and one of aspergillosis. Post-transplant seizures, occurring in a third of the patients, were related to a variety of causative factors such as sepsis, intracranial hemorrhage, cerebral ischemia, metabolic encephalopathy and cyclosporin neurotoxicity. Of note in this series was the absence of CNS lymphoma or other systemic lymphoproliferative disorder.<\/jats:p>","DOI":"10.1017\/s0317167100029115","type":"journal-article","created":{"date-parts":[[2016,7,28]],"date-time":"2016-07-28T11:40:23Z","timestamp":1469706023000},"page":"291-298","source":"Crossref","is-referenced-by-count":20,"title":["Neuropathology of Heart Transplantation"],"prefix":"10.1017","volume":"16","author":[{"given":"L.C.","family":"Ang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.M.","family":"Gillett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.C.E.","family":"Kaufmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2015,9,18]]},"reference":[{"key":"S0317167100029115_ref017","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410240602"},{"key":"S0317167100029115_ref020","first-page":"2748","article-title":"Complications of cyclosporin therapy-A comparison to Azathioprine","volume":"5","author":"Laupacis","year":"1983","journal-title":"Transplant Proc"},{"key":"S0317167100029115_ref022","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410090203"},{"key":"S0317167100029115_ref009","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197502)35:2<291::AID-CNCR2820350202>3.0.CO;2-V"},{"key":"S0317167100029115_ref018","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0022-5223(19)37440-9","article-title":"Powerful but limited immunosuppression for cardiac transplantation with cyclosporin and low-dose steroid","volume":"7","author":"Griffith","year":"1984","journal-title":"J Thorac Cardiovasc Surg"},{"key":"S0317167100029115_ref025","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(81)80238-9"},{"key":"S0317167100029115_ref012","doi-asserted-by":"publisher","DOI":"10.1136\/thx.18.4.291"},{"key":"S0317167100029115_ref046","first-page":"2559","article-title":"Cyclosporine for cardiac transplantation: the United Kingdom trial","volume":"15","author":"Wallwork","year":"1983","journal-title":"Transplant Proc"},{"key":"S0317167100029115_ref043","first-page":"873","article-title":"Cytomegalovirus induced demyelination associated with acquired immunedeficiency syndrome","volume":"108","author":"Moskowitz","year":"1984","journal-title":"Arch Pathol Lab Med"},{"key":"S0317167100029115_ref029","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1967.00470280080008"},{"key":"S0317167100029115_ref010","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.11.5.433"},{"key":"S0317167100029115_ref036","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)92263-5"},{"key":"S0317167100029115_ref032","doi-asserted-by":"publisher","DOI":"10.1007\/BF00314250"},{"key":"S0317167100029115_ref031","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.30.12.1292"},{"key":"S0317167100029115_ref039","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19810915)48:6<1318::AID-CNCR2820480612>3.0.CO;2-R"},{"key":"S0317167100029115_ref037","first-page":"116","article-title":"Cyclosporine neurotoxicity in liver transplant recipients: report of three cases","volume":"20","author":"Deierhoi","year":"1988","journal-title":"Transplant Proc"},{"key":"S0317167100029115_ref004","first-page":"2553","article-title":"Experience with cyclosporin in cardiac transplantation","volume":"15","author":"Hardesty","year":"1983","journal-title":"Transplant Proc"},{"key":"S0317167100029115_ref047","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1983.03330370056032"},{"key":"S0317167100029115_ref013","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196503112721001"},{"key":"S0317167100029115_ref014","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/89.2.235"},{"key":"S0317167100029115_ref042","first-page":"192","article-title":"Focal pontine leukoencephalopathy in immunosuppressed patients","volume":"111","author":"Vinters","year":"1978","journal-title":"Arch Pathol Lab Med"},{"key":"S0317167100029115_ref011","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.6135.457"},{"key":"S0317167100029115_ref027","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1954.tb03153.x"},{"key":"S0317167100029115_ref035","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)92053-7"},{"key":"S0317167100029115_ref016","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1973.00490190028002"},{"key":"S0317167100029115_ref044","first-page":"806","article-title":"The neuropathology of liver, heart and heart-lung transplantation","volume":"20","author":"Martinez","year":"1988","journal-title":"Transplant Proc"},{"key":"S0317167100029115_ref005","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/99.4.673"},{"key":"S0317167100029115_ref001","first-page":"1271","article-title":"The operation. 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