{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:20:28Z","timestamp":1791278428102,"version":"4.1.0"},"reference-count":30,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2015,9,18]],"date-time":"2015-09-18T00:00:00Z","timestamp":1442534400000},"content-version":"unspecified","delay-in-days":9271,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. j. neurol. sci."],"published-print":{"date-parts":[[1990,5]]},"abstract":"<jats:title>ABSTRACT:<\/jats:title><jats:p>Fifty patients with malignant supratentorial tumours were treated with intra-operative photodynamic therapy (PDT); in 33 cases the tumour was recurrent. In 45 patients the tumour was a cerebral glioma and in 5 cases a solitary cerebral metastasis. All patients received a porphyrin photosensitizer 18-24 hours pre-operatively. Photoillumination was carried out at 630 nm to a tumour cavity created by radical tumour resection and\/or tumour cyst drainage. The light energy density ranged from 8 to 175 J\/cm<jats:sup>2<\/jats:sup>. In 8 patients additional interstitial light was administered. The operative mortality was 4%. Follow up has ranged from 1 to 30 months. The median survival for the 45 primary malignant tumours was 8.6 months with a 1 and 2 year actuarial survival rate of 32% and 18%, respectively. In 12 patients a complete or near complete CT scan response was identified post PDT. These patients tended to have a tumour geometry (eg. cystic) that allowed complete or near complete light distribution to the tumour. The median survival for this group was 17.1 months with a 1 and 2 year actuarial survival of 62% and 38%, respectively. In the 33 cases who did not have a complete response the median survival was 6.5 months with a 1 and 2 year actuarial survival of 22% and 11%, respectively. Photodynamic therapy of malignant brain tumours can be carried out with acceptable risk. Good responses appear to be related to adequate light delivery to the tumour.<\/jats:p>","DOI":"10.1017\/s0317167100030444","type":"journal-article","created":{"date-parts":[[2016,7,28]],"date-time":"2016-07-28T11:41:03Z","timestamp":1469706063000},"page":"193-198","source":"Crossref","is-referenced-by-count":64,"title":["Photodynamic Therapy of Malignant Brain Tumours"],"prefix":"10.1017","volume":"17","author":[{"given":"Paul J.","family":"Muller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian C.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2015,9,18]]},"reference":[{"key":"S0317167100030444_ref029","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19850815)56:4<758::AID-CNCR2820560410>3.0.CO;2-2"},{"key":"S0317167100030444_ref027","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19821201)50:11<2301::AID-CNCR2820501114>3.0.CO;2-J"},{"key":"S0317167100030444_ref025","first-page":"411","article-title":"Third national cancer survey. 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