{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T05:23:47Z","timestamp":1767677027473},"reference-count":15,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2015,9,18]],"date-time":"2015-09-18T00:00:00Z","timestamp":1442534400000},"content-version":"unspecified","delay-in-days":9087,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. j. neurol. sci."],"published-print":{"date-parts":[[1990,11]]},"abstract":"<jats:title>ABSTRACT:<\/jats:title><jats:p>The mechanism for the preferential distribution of emboli to cerebral arterial bordcrzone regions, known to cause some watershed infarcts was studied. We hypothesized that emboli of a specific size range are selectively directed to the arterial borderzones due to the tendency of emboli to bypass the small arterial branches which emerge proximal to major borderzones. To test this hypothesis we perfused the brains of cadavers with suspensions of 90-210 \u00b5m glass microspheres and chemically extracted the particles from various arterial territories and a watershed zone. Particles in the 150-210 \u00b5m size range were found to be preferentially distributed to the watershed zone whereas particles less than 150 \u00b5m in size were randomly dispersed in leptomeningeal arteries of all vascular regions. To assess the role of branch size on the concentration of emboli at bifurcations, we perfused artificial analogs of evenly and unevenly branching bifurcations with suspensions of 90-150 \u00b5m and 150-210 \u00b5m particles. Branching cylinders with symmetrical branches contained the same concentration of particles, independent of particle size. In contrast, when one branch was one-quarter the size of the other, the concentration of 150-210 \u00b5m particles in the asymmetric branch was approximately 65% of the main trunk. Particles 90-150 \u00b5m in size were evenly distributed despite variation in branch size. These results indicate that emboli, of a limited range of size, may be selectively propagated to the distal ramifications of subarachnoid arteries located in the watershed zone rather than diverging into small calibre branches which arise along the way.<\/jats:p>","DOI":"10.1017\/s031716710003095x","type":"journal-article","created":{"date-parts":[[2016,7,28]],"date-time":"2016-07-28T11:41:22Z","timestamp":1469706082000},"page":"395-398","source":"Crossref","is-referenced-by-count":52,"title":["The Mechanism of Embolic Watershed Infarction: Experimental Studies"],"prefix":"10.1017","volume":"17","author":[{"given":"M.S.","family":"Pollanen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.H.N.","family":"Deck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2015,9,18]]},"reference":[{"key":"S031716710003095X_ref014","first-page":"89","volume-title":"Biomedical Fluid Mechanics Symposium","author":"Charm","year":"1966"},{"key":"S031716710003095X_ref009","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.20.12.1209"},{"key":"S031716710003095X_ref005","first-page":"99","article-title":"Watershed infarcts in the brain caused by microemboli","volume":"1","author":"Torvik","year":"1982","journal-title":"Clin Neuropathol"},{"key":"S031716710003095X_ref011","doi-asserted-by":"publisher","DOI":"10.1126\/science.143.3605.469"},{"key":"S031716710003095X_ref007","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.31.7.860"},{"key":"S031716710003095X_ref004","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.15.2.221"},{"key":"S031716710003095X_ref001","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/89.2.269"},{"key":"S031716710003095X_ref008","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/S0022-5223(19)40153-0","article-title":"Fatal cerebral atheromatous embolization after cardiopulmonary bypass","volume":"71","author":"McKinnon","year":"1976","journal-title":"J Thorac Cardiovas Surg"},{"key":"S031716710003095X_ref003","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/89.2.235"},{"key":"S031716710003095X_ref010","first-page":"87","volume-title":"Blood Flow and Microcirculation","author":"Charm","year":"1974"},{"key":"S031716710003095X_ref012","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-195910000-00005"},{"key":"S031716710003095X_ref013","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511896996"},{"key":"S031716710003095X_ref015","doi-asserted-by":"publisher","DOI":"10.1017\/S002211206200110X"},{"key":"S031716710003095X_ref002","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/103.4.929"},{"key":"S031716710003095X_ref006","first-page":"1139","article-title":"Directed embolization is an alternate cause of cerebral watershed infarction","volume":"113","author":"Pollanen","year":"1989","journal-title":"Arch Pathol Lab Med"}],"container-title":["Canadian Journal of Neurological Sciences \/ Journal Canadien des Sciences Neurologiques"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S031716710003095X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T01:32:19Z","timestamp":1656898339000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S031716710003095X\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,11]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1990,11]]}},"alternative-id":["S031716710003095X"],"URL":"https:\/\/doi.org\/10.1017\/s031716710003095x","relation":{},"ISSN":["0317-1671","2057-0155"],"issn-type":[{"value":"0317-1671","type":"print"},{"value":"2057-0155","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,11]]}}}