{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:21:42Z","timestamp":1790612502019,"version":"4.1.0"},"reference-count":7,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2015,9,18]],"date-time":"2015-09-18T00:00:00Z","timestamp":1442534400000},"content-version":"unspecified","delay-in-days":6530,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. j. neurol. sci."],"published-print":{"date-parts":[[1997,11]]},"abstract":"<jats:title>ABSTRACT:<\/jats:title>\n\t  <jats:sec id=\"S0317167100033035_abs1\">\n\t    <jats:title>Background:<\/jats:title>\n\t    <jats:p>CSF shunting procedures are generally considered the fundamental therapy of syphilitic hydrocephalus.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0317167100033035_abs2\">\n\t    <jats:title>Methods:<\/jats:title>\n\t    <jats:p>We followed up with CSF analysis and MR imaging a patient with progressive mental and gait disturbances and tetraventricular hydrocephalus due to tertiary syphilis who was treated for 14 days with high dose intravenous penicillin alone.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0317167100033035_abs3\">\n\t    <jats:title>Results:<\/jats:title>\n\t    <jats:p>Clinical and CSF abnormalities resolved within a few months, whereas the hydrocephalus disappeared only 30 months after therapy.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0317167100033035_abs4\">\n\t    <jats:title>Conclusions:<\/jats:title>\n\t    <jats:p>Before consideration of a CSF shunting procedure, a trial of high dose intravenous penicillin is warranted for patients with syphilitic hydrocephalus.<\/jats:p>\n\t  <\/jats:sec>","DOI":"10.1017\/s0317167100033035","type":"journal-article","created":{"date-parts":[[2016,2,17]],"date-time":"2016-02-17T09:20:51Z","timestamp":1455700851000},"page":"343-344","source":"Crossref","is-referenced-by-count":10,"title":["Reversal of Syphilitic Hydrocephalus with Intravenous Penicillin"],"prefix":"10.1017","volume":"24","author":[{"given":"Mirco","family":"Cosottini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Mascalchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetano","family":"Zaccara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graziano","family":"Arnetoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2015,9,18]]},"reference":[{"key":"S0317167100033035_manual_ref-5","first-page":"273","volume-title":"Handbook of Clinical Neurology","volume":"52","author":"Goodman","year":"1988"},{"key":"S0317167100033035_manual_ref-2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.42.6.501"},{"key":"S0317167100033035_manual_ref-4","first-page":"337","volume-title":"Handbook of Clinical Neurology","volume":"33","author":"Storm-Matthisen","year":"1978"},{"key":"S0317167100033035_manual_ref-7","doi-asserted-by":"publisher","DOI":"10.1007\/BF01406018"},{"key":"S0317167100033035_manual_ref-8","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1985.04060060112021"},{"key":"S0317167100033035_manual_ref-3","first-page":"54","article-title":"Hydroc\u00e8phalic communicante r\u00e9v\u00e9latrice d\u2019une neurosyphilis","volume":"146","author":"Lamy","year":"1990","journal-title":"Rev Neurol"},{"key":"S0317167100033035_manual_ref-6","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/55.3.367"}],"container-title":["Canadian Journal of Neurological Sciences \/ Journal Canadien des Sciences Neurologiques"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0317167100033035","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T03:41:24Z","timestamp":1750477284000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0317167100033035\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,11]]},"references-count":7,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1997,2]]}},"alternative-id":["S0317167100033035"],"URL":"https:\/\/doi.org\/10.1017\/s0317167100033035","relation":{},"ISSN":["0317-1671","2057-0155"],"issn-type":[{"value":"0317-1671","type":"print"},{"value":"2057-0155","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,11]]}}}