{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T12:39:08Z","timestamp":1760013548015},"reference-count":10,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2015,9,18]],"date-time":"2015-09-18T00:00:00Z","timestamp":1442534400000},"content-version":"unspecified","delay-in-days":6438,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. j. neurol. sci."],"published-print":{"date-parts":[[1998,2]]},"abstract":"<jats:title>ABSTRACT:<\/jats:title><jats:sec id=\"S0317167100033539_abs1\"><jats:title>Background:<\/jats:title><jats:p>Cerebrovascular complications of meningitis have been most extensively documented in the setting of acute bacterial or chronic tuberculous meningitis. Involvement of major cerebral vessels is rare and basilar artery thrombosis has not been reported in fungal meningitis secondary to Candida infection.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100033539_abs2\"><jats:title>Methods:<\/jats:title><jats:p>We describe the clinical course and neuropathological findings in a woman with chronic meningitis due to Candida albicans.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100033539_abs3\"><jats:title>Results:<\/jats:title><jats:p>The diagnosis remained elusive antemortem despite analysis of 7 large volume CSF samples and examination of a meningeal and cortical biopsy. Death followed extensive brainstem and temporo-occipital infarction secondary to basilar artery thrombosis. The basilar artery occlusion was secondary to an intense, granulomatous and necrotizing basal meningitis focally extending to the media and intima.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100033539_abs4\"><jats:title>Conclusions:<\/jats:title><jats:p>This paroxysmal and devastating complication of untreated chronic candida meningitis reinforces that a trial of empirical therapy with both antituberculous and antifungal agents should be considered in most cases of chronic culture-negative lymphocytic meningitis.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0317167100033539","type":"journal-article","created":{"date-parts":[[2016,2,17]],"date-time":"2016-02-17T09:11:29Z","timestamp":1455700289000},"page":"76-78","source":"Crossref","is-referenced-by-count":14,"title":["Vasculitic Basilar Artery Thrombosis in Chronic<i>Candida Albicans<\/i>Meningitis"],"prefix":"10.1017","volume":"25","author":[{"given":"D.A.","family":"Grimes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Lach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.R.","family":"Bourque","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2015,9,18]]},"reference":[{"key":"S0317167100033539_ref008","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.23.8.1175"},{"key":"S0317167100033539_ref004","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/S0891-5520(20)30377-9","article-title":"Fungal meningitis","volume":"4","author":"Treseler","year":"1990","journal-title":"Infect Dis Clin North Am"},{"key":"S0317167100033539_ref005","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/70.1.31"},{"key":"S0317167100033539_ref002","doi-asserted-by":"publisher","DOI":"10.1001\/archneurpsyc.1958.02340030014002"},{"key":"S0317167100033539_ref010","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199201093260202"},{"key":"S0317167100033539_ref006","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/19.1.60"},{"key":"S0317167100033539_ref001","first-page":"427","article-title":"Candida albicans infection confused with tuberculosis","volume":"35","author":"Miale","year":"1943","journal-title":"Arch Pathol"},{"key":"S0317167100033539_ref003","first-page":"838","article-title":"Some uncommon forms of cerebral vascular disease","volume":"24","author":"Feigin","year":"1957","journal-title":"J Mt Sinai Hosp"},{"key":"S0317167100033539_ref007","first-page":"900","article-title":"Candida meningitis with cerebral arteritis","volume":"75","author":"Edelson","year":"1975","journal-title":"N Y State J Med"},{"key":"S0317167100033539_ref009","first-page":"283","article-title":"Chronic meningitis without predisposing illness \u2013 a review of 83 cases","volume":"63","author":"Anderson","year":"1987","journal-title":"Q J Med"}],"container-title":["Canadian Journal of Neurological Sciences \/ Journal Canadien des Sciences Neurologiques"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0317167100033539","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,4]],"date-time":"2022-06-04T10:04:37Z","timestamp":1654337077000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0317167100033539\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,2]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1998,2]]}},"alternative-id":["S0317167100033539"],"URL":"https:\/\/doi.org\/10.1017\/s0317167100033539","relation":{},"ISSN":["0317-1671","2057-0155"],"issn-type":[{"value":"0317-1671","type":"print"},{"value":"2057-0155","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,2]]}}}