{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T03:21:12Z","timestamp":1762917672001},"reference-count":31,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2015,9,18]],"date-time":"2015-09-18T00:00:00Z","timestamp":1442534400000},"content-version":"unspecified","delay-in-days":6165,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. j. neurol. sci."],"published-print":{"date-parts":[[1998,11]]},"abstract":"<jats:title>ABSTRACT:<\/jats:title><jats:sec id=\"S0317167100034284_abs1\"><jats:title>Objective:<\/jats:title><jats:p>To compare mild vs. severe non-lesional temporal lobe epilepsy (TLE).<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100034284_abs2\"><jats:title>Methods:<\/jats:title><jats:p>Data from 104 consecutive patients with non-lesional TLE were reviewed. Seventy-three of the 104 fulfilled the criteria for inclusion in this study of a follow-up period longer than three years at our Institute. Patients were considered to have a mild TLE if they were seizure free for at least three years after appropriate antiepileptic medication, or had rare (\u2264 2\/year) complex partial or secondarily generalized seizures for at least three years with or without appropriate antiepileptic therapy. Clinical, EEG and MRI data of mild vs. severe non-lesional TLE patients were compared on the basis of a cross-sectional study design.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100034284_abs3\"><jats:title>Results:<\/jats:title><jats:p>Of the 73 patients with non-lesional TLE included in the study, 43 (59%) had mild TLE, and 30 (41%) had severe TLE. Duration of epilepsy was significantly shorter (mean 15.2 \u00b1 10.5 years vs. 26.4 \u00b1 13.2 years) and age at onset was significantly higher (mean 34.3 \u00b1 15.3 years vs. 7.8 \u00b1 6.8 years) in mild than in severe TLE group. Patients with mild TLE had also a significantly higher prevalence of positive family history of epilepsy (37.2% vs. 10%), and a significantly lower occurrence rate of febrile convulsions (FC) (4.7% vs. 33.3%), mesial temporal sclerosis (MTS) (6.9% vs. 36.7%), and intelligence deficiency (0% vs. 20%). In mild TLE there was also a significantly high rate (58.1% vs. 0%) of delayed diagnosis (from 1 to 28 years), because of misdiagnosis (39.5%) or no medical counseling (18.6%).<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100034284_abs4\"><jats:title>Conclusions:<\/jats:title><jats:p>Mild non-lesional TLE is a common, unrecognized disorder mainly characterized by both onset in adulthood and high prevalence of familial history of epilepsy. The present findings suggest that mild non-lesional TLE may represent a clinical entity different from severe non-lesional TLE.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0317167100034284","type":"journal-article","created":{"date-parts":[[2016,2,17]],"date-time":"2016-02-17T09:23:13Z","timestamp":1455700993000},"page":"282-286","source":"Crossref","is-referenced-by-count":41,"title":["Mild Non-lesional Temporal Lobe Epilepsy: A Common, Unrecognized Disorder with Onset in Adulthood"],"prefix":"10.1017","volume":"25","author":[{"given":"Umberto","family":"Aguglia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Gambardella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilio 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