{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T13:57:01Z","timestamp":1756994221362},"reference-count":18,"publisher":"Cambridge University Press (CUP)","issue":"S4","license":[{"start":{"date-parts":[[2015,9,18]],"date-time":"2015-09-18T00:00:00Z","timestamp":1442534400000},"content-version":"unspecified","delay-in-days":11278,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Neurol. Sci."],"published-print":{"date-parts":[[1984,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We measured the activity of cytosolic and of mitochondrial malic enzyme in the hearts from 4 patients with Friedreich's disease and from two non-ataxic control subjects. There was a wide variability in the results and the slight overall decreases in both enzyme activities were not considered to be statistically significant. From these and other results, we conclude that deficient mitochondrial malic enzyme activity is not a constant or primary feature of Friedreich's disease.<\/jats:p>","DOI":"10.1017\/s0317167100035216","type":"journal-article","created":{"date-parts":[[2016,7,28]],"date-time":"2016-07-28T11:36:16Z","timestamp":1469705776000},"page":"643-645","source":"Crossref","is-referenced-by-count":1,"title":["Cardiac malic enzyme in Friedreich's disease"],"prefix":"10.1017","volume":"11","author":[{"given":"A.","family":"Barbeau","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Charbonneau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Cloutier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Lemieux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2015,9,18]]},"reference":[{"key":"S0317167100035216_ref014","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100119596"},{"key":"S0317167100035216_ref012","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100035204"},{"key":"S0317167100035216_ref011","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100043833"},{"key":"S0317167100035216_ref010","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100022927"},{"key":"S0317167100035216_ref008","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/91.4.803"},{"key":"S0317167100035216_ref004","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.33.6.712"},{"key":"S0317167100035216_ref003","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100044048"},{"key":"S0317167100035216_ref001","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1017\/S0317167100024963","article-title":"Emerging treatments: replacement therapy with choline or lecithin in neurological diseases","volume":"5","author":"Barbeau","year":"1978","journal-title":"Can J Neurol Sci"},{"key":"S0317167100035216_ref005","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1971.tb01347.x"},{"key":"S0317167100035216_ref002","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100023064"},{"key":"S0317167100035216_ref006","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(73)90628-0"},{"key":"S0317167100035216_ref018","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.33.6.780"},{"key":"S0317167100035216_ref007","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100025464"},{"key":"S0317167100035216_ref017","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.32.3.221"},{"key":"S0317167100035216_ref013","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100043870"},{"key":"S0317167100035216_ref016","first-page":"283","article-title":"Mitochondrial malic enzyme deficiency in Friedreich\u2019s Ataxia","volume":"10","author":"Stumpf","year":"1981","journal-title":"Ann Neurol"},{"key":"S0317167100035216_ref015","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(82)90037-0"},{"key":"S0317167100035216_ref009","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100119742"}],"container-title":["Canadian Journal of Neurological Sciences \/ Journal Canadien des Sciences Neurologiques"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0317167100035216","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,11]],"date-time":"2019-09-11T21:11:51Z","timestamp":1568236311000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0317167100035216\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,11]]},"references-count":18,"journal-issue":{"issue":"S4","published-print":{"date-parts":[[1984,11]]}},"alternative-id":["S0317167100035216"],"URL":"https:\/\/doi.org\/10.1017\/s0317167100035216","relation":{},"ISSN":["0317-1671","2057-0155"],"issn-type":[{"value":"0317-1671","type":"print"},{"value":"2057-0155","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,11]]}}}