{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:30:38Z","timestamp":1790382638088,"version":"4.1.0"},"reference-count":25,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2015,9,18]],"date-time":"2015-09-18T00:00:00Z","timestamp":1442534400000},"content-version":"unspecified","delay-in-days":10913,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. j. neurol. sci."],"published-print":{"date-parts":[[1985,11]]},"abstract":"<jats:title>ABSTRACT:<\/jats:title><jats:p>Twelve fatal cases of encephalopathy associated with sepsis were examined in a ten-year retrospective study. The sources of infection and organisms isolated were variable. Six of the patients had focal neurologic signs; five had seizures. The level of consciousness varied from drowsiness to deep coma, and electroencephalograms revealed diffuse or multifocal abnormalities. Computed tomographic head scans and cerebrospinal fluid examinations were usually unremarkable. Eight patients had disseminated microabscesses in the brain at autopsy. Four patients had proliferation of astrocytes and microglia in the cerebral cortex, a feature associated with metabolic encephalopathies. Additional findings included cerebral infarcts, brain purpura, multiple small white matter hemorrhages, and central pontine myelinolysis. Although sepsis may cause encephalopathy by producing disturbances in cerebral synaptic transmission and cerebral energy production through a toxic mechanism, bacterial invasion of the brain with the formation of disseminated microabscesses is also an important cause.<\/jats:p>","DOI":"10.1017\/s0317167100035381","type":"journal-article","created":{"date-parts":[[2016,7,28]],"date-time":"2016-07-28T11:37:16Z","timestamp":1469705836000},"page":"303-307","source":"Crossref","is-referenced-by-count":114,"title":["The Encephalopathy of Sepsis"],"prefix":"10.1017","volume":"12","author":[{"given":"Alan C.","family":"Jackson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph J.","family":"Gilbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Bryan","family":"Young","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles F.","family":"Bolton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2015,9,18]]},"reference":[{"key":"S0317167100035381_ref006","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198103263041307"},{"key":"S0317167100035381_ref005","doi-asserted-by":"publisher","DOI":"10.1001\/archneurpsyc.1928.02210150084005"},{"key":"S0317167100035381_ref016","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-101-5-653"},{"key":"S0317167100035381_ref001","first-page":"33","volume-title":"Introduction to Neuropathology","author":"Adams","year":"1968"},{"key":"S0317167100035381_ref008","first-page":"133","article-title":"The metabolic basis of severe sepsis in man","volume":"9","author":"Finley","year":"1976","journal-title":"Ann R Coll Phys Surg Can"},{"key":"S0317167100035381_ref011","first-page":"225","article-title":"Action of bacterial endotoxin on mitochondrial enzymic processes","volume":"25","author":"Kato","year":"1972","journal-title":"Jpn J Med Sci Biol"},{"key":"S0317167100035381_ref023","first-page":"256","volume-title":"Oxygen Supply","author":"Schmahl","year":"1973"},{"key":"S0317167100035381_ref015","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1128\/MMBR.48.3.199-221.1984","article-title":"Bacterial toxins: cellular mechanisms of action","volume":"48","author":"Middlebrook","year":"1984","journal-title":"Microbiol Rev"},{"key":"S0317167100035381_ref002","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-194407000-00002"},{"key":"S0317167100035381_ref020","first-page":"310","article-title":"Remote organ failure: A valid sign of occult intra-abdominal infection","volume":"81","author":"Polk","year":"1977","journal-title":"Surgery"},{"key":"S0317167100035381_ref018","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1983.01390020084014"},{"key":"S0317167100035381_ref003","doi-asserted-by":"publisher","DOI":"10.1126\/science.178.4061.621"},{"key":"S0317167100035381_ref007","first-page":"323","article-title":"Multiple organ failure","volume":"144","author":"Eiseman","year":"1977","journal-title":"Surg Gynecol Obstet"},{"key":"S0317167100035381_ref009","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410020108"},{"key":"S0317167100035381_ref012","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(73)90020-8"},{"key":"S0317167100035381_ref025","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197006010-00008"},{"key":"S0317167100035381_ref010","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(81)90026-X"},{"key":"S0317167100035381_ref019","volume-title":"The Diagnosis of Stupor and Coma","author":"Plum","year":"1980"},{"key":"S0317167100035381_ref004","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.47.11.1223"},{"key":"S0317167100035381_ref021","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197807000-00004"},{"key":"S0317167100035381_ref024","first-page":"650","article-title":"Physiologische und elektronenmikroskopische Befunde an der Hirnrinde beim experi-mentellen Endotoxinschock","volume":"78","author":"Schmahl","year":"1972","journal-title":"Verh Dtsch Ges Inn Med"},{"key":"S0317167100035381_ref013","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410160102"},{"key":"S0317167100035381_ref017","first-page":"223","article-title":"Disseminated microabscesses of the central nervous system (Abstract)","volume":"33","author":"Pendlebury","year":"1983","journal-title":"Neurology"},{"key":"S0317167100035381_ref022","first-page":"1","volume-title":"Septic Shock","author":"Sanford","year":"1985"},{"key":"S0317167100035381_ref014","first-page":"15","article-title":"Direct and indirect effects of endotoxin on mitochondrial function","volume":"62","author":"Mela","year":"1981","journal-title":"Prog Clin Biol Res"}],"container-title":["Canadian Journal of Neurological Sciences \/ Journal Canadien des Sciences Neurologiques"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0317167100035381","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T12:38:29Z","timestamp":1600951109000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0317167100035381\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,11]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1985,11]]}},"alternative-id":["S0317167100035381"],"URL":"https:\/\/doi.org\/10.1017\/s0317167100035381","relation":{},"ISSN":["0317-1671","2057-0155"],"issn-type":[{"value":"0317-1671","type":"print"},{"value":"2057-0155","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,11]]}}}