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Consistent and severe involvement of the nucleus basalis of Meynert has been found in Alzheimer's disease and in the dementia accompanying Parkinson's disease. Occasional involvement is present in other dementing illnesses, such as progressive supranuclear palsy, Parkinsonism-Dementia complex of Guam, dementia pugilistica, Pick's disease, Korsakoff's syndrome, Down's Syndrome and Creutzfeldt- Jakob disease. Huntington's disease spares this nucleus. However, the role of the nucleus in cognitive function is as yet undetermined. Even its alteration with normal aging remains controversial. This review details the pathological studies of this region to date, with particular emphasis on the dementias. Its role in the dementias of Alzheimer's disease and Parkinson's disease is specifically addressed.<\/jats:p>","DOI":"10.1017\/s0317167100035721","type":"journal-article","created":{"date-parts":[[2016,7,28]],"date-time":"2016-07-28T11:37:29Z","timestamp":1469705849000},"page":"8-14","source":"Crossref","is-referenced-by-count":49,"title":["The Nucleus Basalis of 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