{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:40:51Z","timestamp":1761709251362},"reference-count":19,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2015,9,18]],"date-time":"2015-09-18T00:00:00Z","timestamp":1442534400000},"content-version":"unspecified","delay-in-days":10640,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. j. neurol. sci."],"published-print":{"date-parts":[[1986,8]]},"abstract":"<jats:title>ABSTRACT:<\/jats:title><jats:p>A sample of 122 patients with Parkinson's Disease was studied for the purpose of investigating if the frequency of relatives affected with Parkinson in this group was higher than in a control group and to see if the genetic load was more important in some of the subtypes of Parkinson described by Barbeau and Pourcher (1982).<jats:sup>7<\/jats:sup>In our 122 patients, we found that 1.7% were post-encephalic parkinsonian, 12.3% were symptomatic cases and 86% of the idiopathic variety. There were 16.1% early onset patients in the idiopathic group and among these we found 23.5% with a positive family history of Parkinson in the first-degree relatives. In 6 cases with the tremor onset form of the disease, the family history was positive and 5 patients, 4.7% had familial essential tremor-related Parkinsonism. Our results support Barbeau's hypothesis<jats:sup>7.19<\/jats:sup>that Parkinson is a heterogeneous disease in which some subtypes (such as early onset Parkinson) have an important genetic subceptibility component.<\/jats:p>","DOI":"10.1017\/s0317167100036362","type":"journal-article","created":{"date-parts":[[2016,7,28]],"date-time":"2016-07-28T07:37:40Z","timestamp":1469691460000},"page":"248-251","source":"Crossref","is-referenced-by-count":40,"title":["Parkinson's Disease: A Genetic Study"],"prefix":"10.1017","volume":"13","author":[{"given":"Ma. 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