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Since polymorphisms in the region 5' to the insulin gene have been associated with blood glucose levels, we have studied this polymorphism in AD patients. Subjects were 19 nondiabetic AD patients with symptoms of aphasia and apraxia and a family history of AD; and 20 age and sex-matched nondiabetic controls without family history of AD. The 5' polymorphic region of the insulin gene was analyzed by restriction enzyme digestion of DNA extracted from whole venous blood. We did not observe a correlation between the size of the 5' polymorphic region and AD.<\/jats:p>","DOI":"10.1017\/s0317167100037148","type":"journal-article","created":{"date-parts":[[2016,7,28]],"date-time":"2016-07-28T07:38:05Z","timestamp":1469691485000},"page":"471-474","source":"Crossref","is-referenced-by-count":0,"title":["Investigation of the Polymorphic Region in the 5' Flanking Region of the Insulin Gene in Patients with Alzheimer's Disease"],"prefix":"10.1017","volume":"13","author":[{"given":"Michael","family":"Fisman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerie M.","family":"Watt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2015,9,18]]},"reference":[{"key":"S0317167100037148_ref016","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.288.6411.96"},{"key":"S0317167100037148_ref018","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(82)91505-7"},{"key":"S0317167100037148_ref011","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(77)90052-3"},{"key":"S0317167100037148_ref005","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(82)92152-3"},{"key":"S0317167100037148_ref019","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)92866-1"},{"key":"S0317167100037148_ref021","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700003081"},{"key":"S0317167100037148_ref025","doi-asserted-by":"publisher","DOI":"10.1038\/306234a0"},{"key":"S0317167100037148_ref015","doi-asserted-by":"publisher","DOI":"10.2337\/diab.31.3.275"},{"key":"S0317167100037148_ref003","first-page":"309","volume-title":"Biological Aspects of Alzheimer\u2019s Disease Banbury Reports","author":"Benson","year":"1983"},{"key":"S0317167100037148_ref022","doi-asserted-by":"publisher","DOI":"10.1159\/000115158"},{"key":"S0317167100037148_ref024","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.36.4.581"},{"key":"S0317167100037148_ref004","first-page":"219","volume-title":"Biological Aspects of Alzheimer\u2019s Disease Banbury Reports","author":"Bowen","year":"1983"},{"key":"S0317167100037148_ref023","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1983.tb00368.x"},{"key":"S0317167100037148_ref012","doi-asserted-by":"publisher","DOI":"10.2337\/diab.33.2.176"},{"key":"S0317167100037148_ref020","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(81)90190-8"},{"key":"S0317167100037148_ref008","first-page":"533","volume-title":"Clinical Psychiatry","author":"Slater","year":"1979"},{"key":"S0317167100037148_ref001","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1983.tb03756.x"},{"key":"S0317167100037148_ref002","first-page":"42","article-title":"Carbohydrate metabolism in Alzheimer\u2019s disease","author":"Fisman","year":"1985","journal-title":"138th Meeting of the Am Psych Assoc Dallas"},{"key":"S0317167100037148_ref006","doi-asserted-by":"publisher","DOI":"10.2337\/diab.34.4.311"},{"key":"S0317167100037148_ref007","doi-asserted-by":"publisher","DOI":"10.1038\/306557a0"},{"key":"S0317167100037148_ref009","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(79)90093-X"},{"key":"S0317167100037148_ref010","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(75)80083-0"},{"key":"S0317167100037148_ref013","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.4.1045"},{"key":"S0317167100037148_ref014","first-page":"245","article-title":"Insulin gene polymorphism and Type II or non-insulin dependent Diabetes mellitus (N1DDM)","author":"Permutt","year":"1985","journal-title":"Proceedings of the Seventh International Congress on Endocrinology"},{"key":"S0317167100037148_ref017","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)90126-0"}],"container-title":["Canadian Journal of Neurological Sciences \/ Journal Canadien des Sciences Neurologiques"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0317167100037148","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,21]],"date-time":"2019-05-21T23:28:41Z","timestamp":1558481321000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0317167100037148\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,11]]},"references-count":25,"journal-issue":{"issue":"S4","published-print":{"date-parts":[[1986,11]]}},"alternative-id":["S0317167100037148"],"URL":"https:\/\/doi.org\/10.1017\/s0317167100037148","relation":{},"ISSN":["0317-1671","2057-0155"],"issn-type":[{"value":"0317-1671","type":"print"},{"value":"2057-0155","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,11]]}}}