{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T06:36:44Z","timestamp":1783406204654,"version":"3.54.6"},"reference-count":22,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2015,9,18]],"date-time":"2015-09-18T00:00:00Z","timestamp":1442534400000},"content-version":"unspecified","delay-in-days":7169,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. j. neurol. sci."],"published-print":{"date-parts":[[1996,2]]},"abstract":"<jats:title>ABSTRACT:<\/jats:title><jats:sec id=\"S0317167100039135_abs1\"><jats:title><jats:italic><jats:bold>Background:<\/jats:bold><\/jats:italic><\/jats:title><jats:p>Previous reports have described changes in reciprocal la inhibition in h\u00e9mipl\u00e9gie patients, but correlations between the amount of la inhibition and the clinical deficits have not been well established.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100039135_abs2\"><jats:title><jats:italic><jats:bold>Methods:<\/jats:bold><\/jats:italic><\/jats:title><jats:p>We studied reciprocal inhibition between ankle flexors (tibialis anterior) and extensors (soleus) in 16 hemiplegic patients at various stages following a stroke and in 26 control subjects. The amount of disynaptic la inhibition was determined from the short latency suppression of the soleus or tibialis anterior H-reflexes by conditioning stimulation of the antagonistic muscle nerves. <\/jats:p><\/jats:sec><jats:sec id=\"S0317167100039135_abs3\"><jats:title><jats:italic><jats:bold>Results:<\/jats:bold><\/jats:italic><\/jats:title><jats:p>Disynaptic la inhibition from peroneal nerve aff\u00e9rents to soleus motoneurones was increased in patients who showed good recovery of function with mild spasticity. However, it was not changed, or even sometimes diminished, in patients who made a poor recovery and had more marked extensor spasticity. In patients where serial recordings were obtained there was an increase in la inhibition during the recovery period following stroke. la inhibition to the tibialis anterior motoneurones tended to be greater in the poor recovery patients with marked spasticity than in the good recovery patients. The late (Dl) inhibition, presumably due to presynaptic inhibition, was decreased in the patients, although consistent correlations between the amount of this inhibition and the clinical features were not clearly demonstrated.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100039135_abs4\"><jats:title><jats:italic><jats:bold>Conclusions:<\/jats:bold><\/jats:italic><\/jats:title><jats:p>Changes in excitability of la inhibitory pathways can be correlated with some of the clinical features seen in hemiplegia. Increased la inhibition of soleus motoneurones during recovery may be a mechanism to compensate for loss of descending motor commands.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0317167100039135","type":"journal-article","created":{"date-parts":[[2016,2,17]],"date-time":"2016-02-17T04:13:08Z","timestamp":1455682388000},"page":"15-23","source":"Crossref","is-referenced-by-count":59,"title":["Reciprocal Inhibition in Hemiplegia: Correlation with Clinical Features and Recovery"],"prefix":"10.1017","volume":"23","author":[{"given":"Yasuyuki","family":"Okuma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert G.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2015,9,18]]},"reference":[{"key":"S0317167100039135_ref036","doi-asserted-by":"publisher","DOI":"10.1007\/BF00237171"},{"key":"S0317167100039135_ref052","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1976.sp011580"},{"key":"S0317167100039135_ref049","first-page":"67","volume-title":"The London symposia (EEG Suppl 39): Elsevier","author":"Tanaka","year":"1987"},{"key":"S0317167100039135_ref048","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(85)90306-4"},{"key":"S0317167100039135_ref053","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1987.sp016680"},{"key":"S0317167100039135_ref033","first-page":"333","volume-title":"Motor Disturbances II","volume":"1990","author":"Lee"},{"key":"S0317167100039135_ref040","doi-asserted-by":"publisher","DOI":"10.1007\/BF00238170"},{"key":"S0317167100039135_ref041","doi-asserted-by":"publisher","DOI":"10.1007\/BF00230924"},{"key":"S0317167100039135_ref039","first-page":"337","article-title":"Pattern of group I fiber connections from ankle flexor and extensor muscles in man","volume":"42","author":"Pierrot-Deseilligny","year":"1981","journal-title":"Exp Brain Res"},{"key":"S0317167100039135_ref038","first-page":"129","volume-title":"Progress in Clinical Neurophysiology","volume":"8","author":"Yanagisawa","year":"1980"},{"key":"S0317167100039135_ref043","doi-asserted-by":"publisher","DOI":"10.1007\/BF00230098"},{"key":"S0317167100039135_ref037","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/99.3.555"},{"key":"S0317167100039135_ref045","first-page":"1","volume-title":"Aids to the examination of the peripheral nervous system","year":"1976"},{"key":"S0317167100039135_ref035","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1971.34.6.1010"},{"key":"S0317167100039135_ref054","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/117.6.1449"},{"key":"S0317167100039135_ref042","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1987.sp016652"},{"key":"S0317167100039135_ref046","first-page":"540","article-title":"Preliminary trial of carisoprodol in multiple sclerosis","volume":"192","author":"Ashworth","year":"1964","journal-title":"Practitioner"},{"key":"S0317167100039135_ref050","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880160702"},{"key":"S0317167100039135_ref044","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(91)90894-Y"},{"key":"S0317167100039135_ref051","first-page":"508","volume-title":"New Developments in Electromyography and Clinical Neurophysiology","volume":"3","author":"Delwaide","year":"1973"},{"key":"S0317167100039135_ref034","first-page":"509","volume-title":"Handbook of Physiology, section 1, The Nervous System","volume":"2","author":"Baldissera"},{"key":"S0317167100039135_ref047","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1989.sp017681"}],"container-title":["Canadian Journal of Neurological Sciences \/ Journal Canadien des Sciences Neurologiques"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0317167100039135","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T15:22:43Z","timestamp":1557760963000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0317167100039135\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,2]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1996,2]]}},"alternative-id":["S0317167100039135"],"URL":"https:\/\/doi.org\/10.1017\/s0317167100039135","relation":{},"ISSN":["0317-1671","2057-0155"],"issn-type":[{"value":"0317-1671","type":"print"},{"value":"2057-0155","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,2]]}}}