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Twenty HIV seropositive patients were studied prospectively to determine the frequency of DSPN in clinical stage II and III of the HIV infection, and to investigate the role of vitamin B<jats:sub>12<\/jats:sub> deficiency on the frequency of DSPN in HIV patients. All patients had complete blood count, serum vitamin B<jats:sub>12<\/jats:sub> level, anti-intrinsic factor antibody, Schilling test, and electrodiagnostic studies including nerve conduction studies and concentric needle examination in the lower extremities, and sympathetic skin responses. Only 1 patient (5%) had clinical and electrophysiological evidence of possible DSPN. Of the 6 patients with abnormal Schilling test, only one had DSPN based on distal sensory symptoms, abnormal neurological examination and electrodiagnostic studies. Evidence for possible DSPN was present in 5% of patients with early HIV infection and did not appear to be more frequent in patients with concurrent vitamin B<jats:sub>12<\/jats:sub> deficiency.<\/jats:p>","DOI":"10.1017\/s0317167100040488","type":"journal-article","created":{"date-parts":[[2016,2,17]],"date-time":"2016-02-17T04:08:29Z","timestamp":1455682109000},"page":"43-46","source":"Crossref","is-referenced-by-count":11,"title":["Sensorimotor Neuropathy and Abnormal Vitamin B<sub>12<\/sub> Metabolism in Early HIV 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