{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T15:16:40Z","timestamp":1794410200460,"version":"4.9.0"},"reference-count":11,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2015,9,18]],"date-time":"2015-09-18T00:00:00Z","timestamp":1442534400000},"content-version":"unspecified","delay-in-days":12193,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. j. neurol. sci."],"published-print":{"date-parts":[[1982,5]]},"abstract":"<jats:title>SUMMARY:<\/jats:title><jats:p>Plasma triglycerides although within the normal range have been shown to be higher in Friedreich\u2019s ataxia than in control subjects. To determine whether this difference could be ascribed to a reduced catabolism of triglyceride-rich lipoproteins, the activities of lipoprotein lipase (LPL) and hepatic triglyceride lipase (HL), released into plasma after an heparin injection, were measured in 13 cases of Friedreich\u2019s ataxia and 14 control subjects of comparable signs. LPL was found to be significantly lower in the ataxic patients. Moreover about half of the cases clustered below the normal range for both lipase activities. This subgroup of Friedreich\u2019s patients had significantly higher plasma triglycerides than those with normal lipase activities. Further studies are needed to relate these findings to other characteristics of the disease.<\/jats:p>","DOI":"10.1017\/s031716710004395x","type":"journal-article","created":{"date-parts":[[2016,7,28]],"date-time":"2016-07-28T11:34:31Z","timestamp":1469705671000},"page":"191-194","source":"Crossref","is-referenced-by-count":7,"title":["Plasma Lipoprotein Lipase and Hepatic Lipase Activities in Friedreich\u2019s Ataxia"],"prefix":"10.1017","volume":"9","author":[{"given":"D.","family":"Blache","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Bouthillier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Barbeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Davignon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2015,9,18]]},"reference":[{"key":"S031716710004395X_ref522","first-page":"177","volume-title":"High density lipoproteins and atherosclerosis","author":"Nikkila","year":"1978"},{"key":"S031716710004395X_ref520","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1017\/S0317167100024951","article-title":"Plasma lipids and lipoproteins in Friedreich\u2019s Ataxia and Familial Spastic Ataxia \u2013 evidence for an abnormal composition of high density lipoproteins","volume":"5","author":"Huang","year":"1978","journal-title":"Can. 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