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Anatomical and physiological studies indicate that fibres from the trigeminal ganglia innervate meninges and vessels within the middle and anterior cranial fossae, especially in the same subfrontal and mesial temporal regions preferentially afflicted in acute herpes encephalitis. These limbic regions are critical for normal memory processing and recall. Explantation and cocultivation techniques have recently demonstrated Herpes simplex virus in many human trigeminal ganglia, which also reveal a life-long lymphocytic infiltration in the absence of any pathological changes in the sensory neurones. These lymphocytes may represent a histological marker of latent herpes virus, which when reactivating is well-established as the ganglionic source of recurrent herpes labialis. It is suggested that reactivation of the same dormant viral material travelling centripetally instead might be the cause of the \u201cdegenerative\u201d lesions typical both of Alzheimer\u2019s Disease and of the normal aged human brain.<\/jats:p>","DOI":"10.1017\/s0317167100044115","type":"journal-article","created":{"date-parts":[[2016,4,8]],"date-time":"2016-04-08T18:19:05Z","timestamp":1460139545000},"page":"303-306","source":"Crossref","is-referenced-by-count":210,"title":["\u201cLimbic Predilection in Alzheimer Dementia: Is Reactivated Herpesvirus Involved?\u201d"],"prefix":"10.1017","volume":"9","author":[{"given":"Melvyn J.","family":"Ball","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2015,9,18]]},"reference":[{"key":"S0317167100044115_ref043","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/95.3.599"},{"key":"S0317167100044115_ref006","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.28.9_Part_2.93"},{"key":"S0317167100044115_ref040","first-page":"99","volume-title":"Congenital and Acquired Cognitive Disorders","author":"Terry","year":"1979"},{"key":"S0317167100044115_ref042","first-page":"280","volume-title":"Alzheimer\u2019s Disease and Related Conditions","author":"Tomlinson","year":"1970"},{"key":"S0317167100044115_ref035","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/89.1.83"},{"key":"S0317167100044115_ref036","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1940.01210040002001"},{"key":"S0317167100044115_ref008","doi-asserted-by":"publisher","DOI":"10.1038\/214470a0"},{"key":"S0317167100044115_ref033","doi-asserted-by":"publisher","DOI":"10.1001\/archneurpsyc.1940.02280070051003"},{"key":"S0317167100044115_ref046","first-page":"1","volume-title":"Ageing and Dementia","author":"Wang","year":"1977"},{"key":"S0317167100044115_ref010","first-page":"37","volume-title":"Alzheimer\u2019s Disease and Related Conditions","author":"Corsellis","year":"1970"},{"key":"S0317167100044115_ref032","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1974.00490390027001"},{"key":"S0317167100044115_ref029","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(80)91490-7"},{"key":"S0317167100044115_ref028","first-page":"298","article-title":"Hippocampus and learning","volume":"3","author":"Meissner","year":"1967","journal-title":"Int. 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