{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T04:40:51Z","timestamp":1785818451423,"version":"3.56.0"},"reference-count":17,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2015,9,18]],"date-time":"2015-09-18T00:00:00Z","timestamp":1442534400000},"content-version":"unspecified","delay-in-days":12101,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. j. neurol. sci."],"published-print":{"date-parts":[[1982,8]]},"abstract":"<jats:title>SUMMARY:<\/jats:title><jats:p>Checkerboard pattern reversal visual evoked potentials (VEPs) have proved useful in the confirmation of optic nerve disease in patients with multiple sclerosis (MS). Recently, evidence of orientation-specific loss in contrast sensitivity and the presence of orientation-specific visual evoked potential (VEP) deficits in MS patients has been obtained using sinusoidal gratings as stimuli. This study reports the presence of orientation-specific VEP delay in MS using the conventional checkerboard pattern presented in two orientations: normally oriented (check condition) or diagonally oriented (diamond condition).<\/jats:p><jats:p>Peak latency values of the N70 and P100 components of the VEP were statistically analyzed using appropriate ANOVA and nonparametric statistics. As a group MS patients showed significant VEP delays under check and diamond pattern conditions. However, individual subject analysis revealed that about 20% of the MS population show VEP delay to only one pattern orientation. It was shown that by including a diamond pattern condition the diagnostic yield of VEP delay in these clinically definite MS patients was increased 11% over that obtained with check stimulation alone.<\/jats:p>","DOI":"10.1017\/s0317167100044164","type":"journal-article","created":{"date-parts":[[2016,7,28]],"date-time":"2016-07-28T11:34:41Z","timestamp":1469705681000},"page":"331-337","source":"Crossref","is-referenced-by-count":18,"title":["Orientation-Specific Visual Evoked Potential Deficits in Multiple Sclerosis"],"prefix":"10.1017","volume":"9","author":[{"given":"Stuart G.","family":"Coupland","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trevor H.","family":"Kirkham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2015,9,18]]},"reference":[{"key":"S0317167100044164_ref143","author":"Siegel","year":"1956"},{"key":"S0317167100044164_ref141","first-page":"324","article-title":"Orientation specific losses of contrast sensitivity in multiple sclerosis","volume":"19","author":"Regan","year":"1980","journal-title":"Invest. 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