{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T09:23:33Z","timestamp":1787909013639,"version":"build-2784847793"},"reference-count":14,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2015,9,18]],"date-time":"2015-09-18T00:00:00Z","timestamp":1442534400000},"content-version":"unspecified","delay-in-days":11828,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. j. neurol. sci."],"published-print":{"date-parts":[[1983,5]]},"abstract":"<jats:title>SUMMARY:<\/jats:title><jats:p>A recent questionnaire survey of the life-effects of narcolepsy in 180 patients, 60 each from North American, Asian and European populations, compared to similarly distributed age and sex matched controls, documented multiple and marked effects on work, education, driving, accidents, recreation, personality, memory and other parameters. The data have now been further analysed according to the patients\u2019 geographic (culturo-genetic) origin and to a number of other patient and illness variables. The three different geographic populations showed few significant differences for the some 160 life-effects items in the questionnaire. This strongly indicates that these are an integral part of the disease or of the human reaction to it. Most of the few significant population differences appeared cultural in origin (e.g., concerning driving records, personality changes), although a few may possibly reflect genetic differences (e.g., visual problems). Analysis of the pooled data according to respondees\u2019 age, sex, age at illness onset, duration of illness and treatment led again to relatively few significant findings. It is concluded that, in general, once the disease has been diagnosed, all the major life effects are present and remain so. The results strongly support the contention that most life-effects are not related to the diagnostic \u2018tetrad\u2019 symptoms themselves but rather to excessive daytime sleepiness, the symptom most resistant to anti-narcoleptic treatment.<\/jats:p>","DOI":"10.1017\/s0317167100044723","type":"journal-article","created":{"date-parts":[[2016,7,28]],"date-time":"2016-07-28T07:35:11Z","timestamp":1469691311000},"page":"100-104","source":"Crossref","is-referenced-by-count":58,"title":["Life Effects of Narcolepsy: Relationships to Geographic Origin (North American, Asian or European) and to Other Patient and Illness Variables"],"prefix":"10.1017","volume":"10","author":[{"given":"Roger","family":"Broughton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quais","family":"Ghanem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuo","family":"Hishikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiro","family":"Sugita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Nevsimalova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bedrich","family":"Roth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2015,9,18]]},"reference":[{"key":"S0317167100044723_ref156","first-page":"126","article-title":"The conception of nervous and mental energy. II. Vigilance: a physiological state of the nervous system","volume":"14","author":"Head","year":"1923","journal-title":"Br. J. Psychol"},{"key":"S0317167100044723_ref150","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/5.S2.S135"},{"key":"S0317167100044723_ref152","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100119304"},{"key":"S0317167100044723_ref158","first-page":"45","article-title":"Heredofamilial aspects of narcolepsy and hypersomnia","volume":"100","author":"Nevsimalova-Bruhova","year":"1972","journal-title":"Arch. Suisses Neurol. Neurochir. Psychiat"},{"key":"S0317167100044723_ref149","first-page":"667","volume-title":"Narcolepsy","author":"Broughton","year":"1976"},{"key":"S0317167100044723_ref154","first-page":"229","author":"Broughton","year":"1980"},{"key":"S0317167100044723_ref148","unstructured":"Battels E.C. and Kusaklioglu O. (1965). Narcolepsy: a possible cause for automobile accidents. Lahey Clin. Found. Bull., 1412\u20131426."},{"key":"S0317167100044723_ref147","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1136\/jmg.15.4.254","article-title":"Genetic study of the narcolepsy syndrome","volume":"15","author":"Baraister","year":"1978","journal-title":"J. Med. Genetics"},{"key":"S0317167100044723_ref155","first-page":"345","volume-title":"Advances in Sleep Research","volume":"174","author":"Guilleminault"},{"key":"S0317167100044723_ref153","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100043419"},{"key":"S0317167100044723_ref157","first-page":"139","article-title":"Monoamines et r\u00e9gulation de la vigilance I. Apport et interpretation biochemique des donn\u00e9es polygraphiques","volume":"172","author":"Mouret","year":"1972","journal-title":"Rev. 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Mayo Clin"}],"container-title":["Canadian Journal of Neurological Sciences \/ Journal Canadien des Sciences Neurologiques"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0317167100044723","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T15:12:38Z","timestamp":1558710758000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0317167100044723\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,5]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1983,5]]}},"alternative-id":["S0317167100044723"],"URL":"https:\/\/doi.org\/10.1017\/s0317167100044723","relation":{},"ISSN":["0317-1671","2057-0155"],"issn-type":[{"value":"0317-1671","type":"print"},{"value":"2057-0155","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,5]]}}}