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Five of 7 patients with acute internuclear ophthalmoplegia due to an initial exacerbation of demyelination have CSF-MBP levels above 6.2 ng\/ml (mean 6.8 ng\/ml). Fifty percent of MS patients with chronic progressive disease have CSF-MBP levels above 6.2 ng\/ml (mean 6.7 ng\/ml). MS patients experiencing monosymptomatic exacerbations show elevated CSF-MBP levels in 75% of cases (mean 8.2 ng\/ml). MS patients experiencing polysymptomatic exacerbations show significantly higher levels of CSF-MBP (mean 22.3 ng\/ml) than the patients with monosymptomatic exacerbations. Ninety-five percent of MS patients experiencing polysymptomatic exacerbations have elevated levels of CSF-MBP.<\/jats:p>","DOI":"10.1017\/s0317167100045066","type":"journal-article","created":{"date-parts":[[2016,7,28]],"date-time":"2016-07-28T11:35:29Z","timestamp":1469705729000},"page":"235-238","source":"Crossref","is-referenced-by-count":22,"title":["CSF Myelin Basic Protein Levels in Acute Optic Neuritis and Multiple Sclerosis"],"prefix":"10.1017","volume":"10","author":[{"given":"K.G.","family":"Warren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Catz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.A.","family":"McPherson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2015,9,18]]},"reference":[{"key":"S0317167100045066_ref84","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.27.10.911"},{"key":"S0317167100045066_ref78","doi-asserted-by":"publisher","DOI":"10.1038\/194495a0"},{"key":"S0317167100045066_ref77","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9120(78)90693-8"},{"key":"S0317167100045066_ref79","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1971.00490040052007"},{"key":"S0317167100045066_ref81","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(78)90008-6"},{"key":"S0317167100045066_ref73","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410080104"},{"key":"S0317167100045066_ref85","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410070111"},{"key":"S0317167100045066_ref75","first-page":"139","article-title":"Large scale preparation of myelin basic protein from central nervous tissue of several mammalian species","volume":"2","author":"Diebler","year":"1972","journal-title":"Prepr. 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