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Most drug interactions are pharmacokinetic, involving changes in absorption, protein binding, metabolism, or excretion. As a result, plasma levels of the antiepileptic drug may decrease leading to exacerbation of seizures. Alternatively, plasma levels may rise resulting in toxic side effects. Similar changes may also occur with drugs given for other disorders. In this paper, possible mechanisms of drug interactions are discussed. This is followed by a description of clinically significant interactions involving phenytoin, carbamazepine, barbiturates, valproic acid, benzodiazepines, and succinimides. Potentially serious drug interactions may be minimized by using as few medications as possible and by regularly monitoring plasma levels of antiepileptic drugs.<\/jats:p>","DOI":"10.1017\/s0317167100045480","type":"journal-article","created":{"date-parts":[[2016,7,28]],"date-time":"2016-07-28T11:35:42Z","timestamp":1469705742000},"page":"247-251","source":"Crossref","is-referenced-by-count":12,"title":["Pharmacokinetic Interactions of Antiepileptic Drugs"],"prefix":"10.1017","volume":"11","author":[{"given":"Penny S.","family":"Albright","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Bruni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2015,9,18]]},"reference":[{"key":"S0317167100045480_ref96","first-page":"77","volume-title":"In: Anticonvulsant Drugs and Enzyme Induction","author":"Hunter","year":"1976"},{"key":"S0317167100045480_ref124","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-85921-2_18"},{"key":"S0317167100045480_ref89","doi-asserted-by":"publisher","DOI":"10.1002\/j.1552-4604.1980.tb02544.x"},{"key":"S0317167100045480_ref83","first-page":"299","volume-title":"In: Antiepileptic Therapy: Advances in Drug Monitoring","author":"Dam","year":"1976"},{"key":"S0317167100045480_ref80","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-25-2-293"},{"key":"S0317167100045480_ref122","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1979.tb04787.x"},{"key":"S0317167100045480_ref84","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1975.tb01385.x"},{"key":"S0317167100045480_ref88","first-page":"165","volume-title":"In: Antiepileptic Drug Monitoring","author":"Flachs","year":"1977"},{"key":"S0317167100045480_ref131","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1091502"},{"key":"S0317167100045480_ref87","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1974.00490330067012"},{"key":"S0317167100045480_ref103","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.16.6.594"},{"key":"S0317167100045480_ref74","doi-asserted-by":"publisher","DOI":"10.1002\/cpt1979265629"},{"key":"S0317167100045480_ref94","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-197612060-00003"},{"key":"S0317167100045480_ref78","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.30.1.94"},{"key":"S0317167100045480_ref126","first-page":"272","volume-title":"In: Handbook of Experimental Pharmacology","volume":"28","author":"Shand","year":"1975"},{"key":"S0317167100045480_ref76","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100042931"},{"key":"S0317167100045480_ref82","doi-asserted-by":"publisher","DOI":"10.1002\/cpt196564420"},{"key":"S0317167100045480_ref86","doi-asserted-by":"publisher","DOI":"10.1007\/BF00606558"},{"key":"S0317167100045480_ref91","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1971.tb46890.x"},{"key":"S0317167100045480_ref85","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197603252941305"},{"key":"S0317167100045480_ref77","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.30.11.1233"},{"key":"S0317167100045480_ref110","first-page":"497","volume-title":"In: Antiepileptic Drugs","author":"Levy","year":"1982"},{"key":"S0317167100045480_ref81","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1973.tb01327.x"},{"key":"S0317167100045480_ref102","doi-asserted-by":"publisher","DOI":"10.1002\/cpt1978245571"},{"key":"S0317167100045480_ref127","doi-asserted-by":"publisher","DOI":"10.1007\/BF00567123"},{"key":"S0317167100045480_ref112","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1975.tb01576.x"},{"key":"S0317167100045480_ref93","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1971.tb04334.x"},{"key":"S0317167100045480_ref75","first-page":"20","article-title":"Diphenylhydantoin intoxication attendant to slow activation of isoniazid","author":"Brennan","year":"1970","journal-title":"Neurology"},{"key":"S0317167100045480_ref97","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5919.584"},{"key":"S0317167100045480_ref73","first-page":"109","article-title":"Effect of benzodiazepines on serum levels of phenobarbital and diphenylhydantoin","volume":"8","author":"Benetello","year":"1977","journal-title":"Riv. 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