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The four drugs tested did not alter the quantity of HRP in the cortex of control animals, or in the contralateral cortex of test animals. However, imidazole, desipramine and trifluoperazine significantly reduced the HRP extravasation in and around the cold lesion. Several mechanisms for this effect are suggested; one possible mechanism common to all these drugs is the reduction of increased vesicular transport in cortical vessels adjacent to the cold lesions.<\/jats:p>","DOI":"10.1017\/s0317167100045984","type":"journal-article","created":{"date-parts":[[2016,7,28]],"date-time":"2016-07-28T11:36:00Z","timestamp":1469705760000},"page":"447-451","source":"Crossref","is-referenced-by-count":11,"title":["Pharmacological Modification of Blood-Brain Barrier Permeability Following a Cold Lesion"],"prefix":"10.1017","volume":"11","author":[{"given":"Jennifer J.","family":"Raymond","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M.","family":"Robertson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry B.","family":"Dinsdale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sukriti","family":"Nag","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2015,9,18]]},"reference":[{"key":"S0317167100045984_ref203","first-page":"280","article-title":"Modification by imidazoles of ocular inflammatory and pressure responses. 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