{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:06:50Z","timestamp":1770822410018,"version":"3.50.1"},"reference-count":12,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2015,9,18]],"date-time":"2015-09-18T00:00:00Z","timestamp":1442534400000},"content-version":"unspecified","delay-in-days":11005,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. j. neurol. sci."],"published-print":{"date-parts":[[1985,8]]},"abstract":"<jats:title>ABSTRACT:<\/jats:title><jats:p>A review of the literature on primary diffuse <jats:italic>meningeal<\/jats:italic> gliomatosis (DMG) yielded three cases and we report a fourth. DMG is a syndrome characterized by extensive basal and spinal chronic meningitis with mental confusion, headaches, diplopia, papilledema and cranial nerve palsies. The cerebrospinal fluid (CSF) has a markedly elevated protein content, moderate mononuclear pleocytosis and a normal or low glucose. This picture invariably leads to the diagnosis and treatment of tuberculous or fungal meningitis despite persistently negative cerebrospinal fluid (CSF) cultures. Reaction of exfoliated CSF cells with glial fibrillary acidic protein (GFAP) immunoperoxidase labelled antibody is suggested as a diagnostic tool. A basal meningeal biopsy appears to be the only alternative diagnostic approach.<\/jats:p>","DOI":"10.1017\/s031716710004717x","type":"journal-article","created":{"date-parts":[[2016,7,28]],"date-time":"2016-07-28T11:37:06Z","timestamp":1469705826000},"page":"278-281","source":"Crossref","is-referenced-by-count":45,"title":["Primary Diffuse Leptomeningeal Gliomatosis"],"prefix":"10.1017","volume":"12","author":[{"given":"Peter","family":"Bailey","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yves","family":"Robitaille","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2015,9,18]]},"reference":[{"key":"S031716710004717X_ref296","first-page":"379","article-title":"The medulloblastoma and the so-called \u201carachnoidal cerebellar sarcoma\u201d","volume":"87","author":"Rubinstein","year":"1964","journal-title":"A critical reexamination of a nosological problem. Brain"},{"key":"S031716710004717X_ref295","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-198301000-00001"},{"key":"S031716710004717X_ref291","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1001\/archneur.1981.00510100090018","article-title":"Primary leptomeningeal gliomatosis","volume":"38","author":"Khang-Loon","year":"1981","journal-title":"Arch Neurol"},{"key":"S031716710004717X_ref290","first-page":"16","article-title":"Heterotopic glial cell nests in the subarachnoid space: Histopathologic characteristics, mode of origin and relation to meningeal gliomas","volume":"10","author":"Cooper","year":"1951"},{"key":"S031716710004717X_ref289","first-page":"183","article-title":"Tumors of the spinal cord: Primary extramedullary gliomas","volume":"92","author":"Cooper","year":"1951","journal-title":"Surg Gynecol Obstet"},{"key":"S031716710004717X_ref294","doi-asserted-by":"publisher","DOI":"10.1016\/S0011-5029(78)80010-8"},{"key":"S031716710004717X_ref297","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.31.2.190"},{"key":"S031716710004717X_ref292","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.7.8.589"},{"key":"S031716710004717X_ref298","first-page":"243","article-title":"Experimental pineocytoma of the Syrian hamster induced by a human papova virus (JC)","volume":"35","author":"Varakis","year":"1976","journal-title":"Acta Neuropathol"},{"key":"S031716710004717X_ref288","first-page":"584","article-title":"Relation of glioma of the leptomeninges to neuroglial nests: Report of a case of an astrocytoma of the leptomeninges","volume":"21","author":"Bailey","year":"1936","journal-title":"Arch Pathol"},{"key":"S031716710004717X_ref299","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.12.1611"},{"key":"S031716710004717X_ref293","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1974.00490320010002"}],"container-title":["Canadian Journal of Neurological Sciences \/ Journal Canadien des Sciences Neurologiques"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S031716710004717X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T21:58:52Z","timestamp":1558562332000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S031716710004717X\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,8]]},"references-count":12,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1985,8]]}},"alternative-id":["S031716710004717X"],"URL":"https:\/\/doi.org\/10.1017\/s031716710004717x","relation":{},"ISSN":["0317-1671","2057-0155"],"issn-type":[{"value":"0317-1671","type":"print"},{"value":"2057-0155","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,8]]}}}