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Several different infusion protocols, each given over a 4 week period were examined: 0.15 M NMDA in phosphate buffered saline; phosphate buffered saline without NMDA; and 0.20 M magnesium sulfate plus 0.15 M NMDA; 0.35 M NMDA. In two additional protocols, 0.15 M NMDA or phosphate buffered saline were infused for a total of 8 weeks. Within 1-2 weeks of the onset of NMDA, but not phosphate buffered saline infusions, the rats exhibited irritability, circling, biting and excessive grooming resulting in loss of hair, and skin ulcerations from autotomy localized to lumbar and sacral innervated dermatomes. Co-infusion of NMDA with magnesium sulfate almost completely prevented these findings. The behavioural changes were not associated with abnormalities of sensory or motor conduction. Intrathecal infusion of NMDA induces a chronic \u201ccentral\u201d experimental pain disorder in rats, localized to the cord segment with the greatest exposure to the infusion, without involvement of peripheral sensory axons and sparing the axonal integrity of anterior horn cells.<\/jats:p>","DOI":"10.1017\/s031716710004871x","type":"journal-article","created":{"date-parts":[[2016,2,17]],"date-time":"2016-02-17T09:12:27Z","timestamp":1455700347000},"page":"24-28","source":"Crossref","is-referenced-by-count":15,"title":["A Segmental Chronic Pain Syndrome in Rats Associated with Intrathecal Infusion of NMDA: evidence for selective action in the dorsal horn"],"prefix":"10.1017","volume":"21","author":[{"given":"Douglas W.","family":"Zochodne","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilyn","family":"Murray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sukriti","family":"Nag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Riopelle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2015,9,18]]},"reference":[{"key":"S031716710004871X_ref003","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(87)90275-9"},{"key":"S031716710004871X_ref015","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(84)90102-3"},{"key":"S031716710004871X_ref017","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(89)90485-0"},{"key":"S031716710004871X_ref014","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902770210"},{"key":"S031716710004871X_ref011","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(79)90002-2"},{"key":"S031716710004871X_ref009","doi-asserted-by":"publisher","DOI":"10.1038\/248740a0"},{"key":"S031716710004871X_ref005","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0022-3565(25)39258-X","article-title":"Nociceptive action of excitatory amino acids in the mouse: effects of spinally administered opioids, phencyclidine and sigma agonists","volume":"243","author":"Aanonsen","year":"1987","journal-title":"J Pharmacol Exp Ther"},{"key":"S031716710004871X_ref001","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.bmb.a072497"},{"key":"S031716710004871X_ref019","volume-title":"The Physiological and Technical Basis of Electromyography","author":"Brown","year":"1984"},{"key":"S031716710004871X_ref006","first-page":"219","volume-title":"NMDA Receptor Related Agents: Biochemistry, Pharmacology and Behaviour","volume":"1991","author":"Sakurada"},{"key":"S031716710004871X_ref016","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(91)90015-P"},{"key":"S031716710004871X_ref012","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(92)90019-5"},{"key":"S031716710004871X_ref007","doi-asserted-by":"publisher","DOI":"10.1007\/BF00662631"},{"key":"S031716710004871X_ref013","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.04-08-02133.1984"},{"key":"S031716710004871X_ref002","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(90)90008-2"},{"key":"S031716710004871X_ref008","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1017\/S0317167100041615","article-title":"The influence of indomethacin and guanethidine on experimental streptozotocin diabetic neuropathy","volume":"19","author":"Zochodne","year":"1992","journal-title":"Can J Neurol Sci"},{"key":"S031716710004871X_ref004","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4899-0597-0"},{"key":"S031716710004871X_ref018","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(91)90281-Y"},{"key":"S031716710004871X_ref010","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(83)90164-1"},{"key":"S031716710004871X_ref020","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199006213222505"}],"container-title":["Canadian Journal of Neurological Sciences \/ Journal Canadien des Sciences Neurologiques"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S031716710004871X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T12:02:13Z","timestamp":1748779333000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S031716710004871X\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,2]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1994,2]]}},"alternative-id":["S031716710004871X"],"URL":"https:\/\/doi.org\/10.1017\/s031716710004871x","relation":{},"ISSN":["0317-1671","2057-0155"],"issn-type":[{"value":"0317-1671","type":"print"},{"value":"2057-0155","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,2]]}}}