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Each is characterized by a distinctive pathologic change and a reasonably wellestablished pathogenesis; in each the role of alcohol in the causation is secondary. The question posed in this review is whether there is, in addition to the established types of dementia associated with alcoholism, a persistent dementia attributable to the direct toxic effects of alcohol on the brain \u2014 i.e., a primary alcoholic dementia. The clinical, psychologic, radiologic, and pathologic evidence bearing on this question is critically reviewed. None of the evidence permits the clear delineation of such an entity. The most serious flaw in the argument for a primary alcoholic dementia is that it lacks a distinctive, well-defined pathology, and it must remain ambiguous until such time as its morphologic basis is established.<\/jats:p>","DOI":"10.1017\/s031716710004899x","type":"journal-article","created":{"date-parts":[[2016,2,17]],"date-time":"2016-02-17T09:29:08Z","timestamp":1455701348000},"page":"88-99","source":"Crossref","is-referenced-by-count":72,"title":["Alcoholic Dementia"],"prefix":"10.1017","volume":"21","author":[{"given":"Maurice","family":"Victor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2015,9,18]]},"reference":[{"key":"S031716710004899X_bib071","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1984.01790180080010"},{"key":"S031716710004899X_bib065","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-3632-7_52"},{"key":"S031716710004899X_bib118","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-198002000-00004"},{"key":"S031716710004899X_bib106","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-198006000-00009"},{"key":"S031716710004899X_bib091","first-page":"524","article-title":"Les atrophies c\u00e9r\u00e9brales des alcooliques","volume":"70","author":"Pluvinage","year":"1954","journal-title":"Bull Soc M\u00e9d H\u00f4p (Paris)"},{"key":"S031716710004899X_bib089","doi-asserted-by":"publisher","DOI":"10.1159\/000104900"},{"key":"S031716710004899X_bib036","first-page":"350","volume-title":"Textbook of Psychiatry","author":"Bleuler","year":"1924"},{"key":"S031716710004899X_bib046","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1176\/ajp.135.1.13","article-title":"Organic brain syndromes\u201d: an empirical study and critical review","volume":"135","author":"Seltzer","year":"1978","journal-title":"Am J Psychiatry"},{"key":"S031716710004899X_bib053","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700017633"},{"key":"S031716710004899X_bib130","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1988.00520330076013"},{"key":"S031716710004899X_bib112","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.1979.136.4b.598"},{"key":"S031716710004899X_bib029","first-page":"393","article-title":"Le syndrome de Marchiafava-Bignami","volume":"77","author":"J\u00e9quier","year":"1956","journal-title":"Schweiz Arch Neurol Neurochir Psychiatr"},{"key":"S031716710004899X_bib035","first-page":"155","volume-title":"Practical Clinical Psychiatry","author":"Strecker","year":"1951"},{"key":"S031716710004899X_bib067","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.107.3.355"},{"key":"S031716710004899X_bib113","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-197710000-00005"},{"key":"S031716710004899X_bib103","doi-asserted-by":"publisher","DOI":"10.1007\/BF00395292"},{"key":"S031716710004899X_bib105","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1989.tb00401.x"},{"key":"S031716710004899X_bib021","first-page":"335","article-title":"The effect of vitamin B6 deficiency induced by desoxypyridoxine in human beings","volume":"42","author":"Vilter","year":"1953","journal-title":"J Lab Clin Med"},{"key":"S031716710004899X_bib041","first-page":"367","volume-title":"American Handbook of Psychiatry","volume":"3","author":"Chafetz","year":"1974"},{"key":"S031716710004899X_bib010","volume-title":"The Wernicke-Korsakoff Syndrome. 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