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SPECT images revealed various patterns of regional cerebral perfusion (rCBF) in the subgroups of patients with the clinical diagnoses of Alzheimer's disease (AD, n = 14), Pick's disease (n = 1), and multi-infarct dementia (n = 7). In three patients, SPECT clarified the clinical differential diagnostic possibilities. Using a relative rCBF quantification technique, the relationship between specific cognitive impairments and rCBF in the AD patients was determined. There was a significant correlation between language impairment and left hemisphere hypoperfusion, whereas, apraxia correlated with hypoperfusion in the left parietal region. Thus, HMPAO SPECT is useful as an aid in the differential diagnosis of dementia and the technique of relative rCBF quantification with SPECT may contribute to the understanding of the clinico-anatomical relations of cognitive deficits in dementia.<\/jats:p>","DOI":"10.1017\/s0317167100049015","type":"journal-article","created":{"date-parts":[[2016,2,17]],"date-time":"2016-02-17T09:29:08Z","timestamp":1455701348000},"page":"104-111","source":"Crossref","is-referenced-by-count":13,"title":["SPECT for Differential Diagnosis of Dementia and Correlation of rCBF with Cognitive Impairment"],"prefix":"10.1017","volume":"21","author":[{"given":"Alicia","family":"Osimani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Ichise","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dae-Gyun","family":"Chung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janice M.","family":"Pogue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morris","family":"Freedman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2015,9,18]]},"reference":[{"key":"S0317167100049015_bib011","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.39.11.1427"},{"key":"S0317167100049015_bib041","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)92357-8"},{"key":"S0317167100049015_bib033","first-page":"230","article-title":"Correlation of positron emission scans with CT scans and clinical course","volume":"60","author":"Ackerman","year":"1979","journal-title":"Acta Neurol Scand"},{"key":"S0317167100049015_bib015","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410150732"},{"key":"S0317167100049015_bib043","article-title":"Effects of human aging on patterns of local cerebral glucose utilization determined by the [l8F]fluorodeoxyglucose method (abst)","volume":"7","author":"Kuhl","year":"1987","journal-title":"J Cereb Blood Flow Metab"},{"key":"S0317167100049015_bib049","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410110607"},{"key":"S0317167100049015_bib016","first-page":"196","article-title":"Quantifying local cerebral blood by n-isopropyl-p(1123) iodoamphetamine (IMP) tomography","volume":"23","author":"Kuhl","year":"1986","journal-title":"J Nucl Med"},{"key":"S0317167100049015_bib044","article-title":"Changes in local cerebral glucose metabolism with normal aging, the effects of cardiovascular and systemic health factors [abst]","volume":"7","author":"Chawluk","year":"1987","journal-title":"J Cereb Blood Flow Metab"},{"key":"S0317167100049015_bib031","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.33.8.961"},{"key":"S0317167100049015_bib030","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1985.25"},{"key":"S0317167100049015_bib007","first-page":"761","article-title":"Application of iodine-123-labelled isopropylamphetamine imaging to the study of dementia","volume":"27","author":"Sharp","year":"1986","journal-title":"J Nucl Med"},{"key":"S0317167100049015_bib005","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-198705000-00005"},{"key":"S0317167100049015_bib040","first-page":"29","article-title":"The Assessment of Aphasia and Related Disorders","author":"Goodglass","year":"1983","journal-title":"Philadelphia: Lea and Febiger"},{"key":"S0317167100049015_bib050","doi-asserted-by":"publisher","DOI":"10.1097\/00003072-198907000-00003"},{"key":"S0317167100049015_bib026","doi-asserted-by":"publisher","DOI":"10.1109\/TNS.1978.4329385"},{"key":"S0317167100049015_bib013","first-page":"855","article-title":"Perfusion and receptor SPECT in the dementias. 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