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HLA DR3 was associated with the familial dementia of the Alzheimer type patients. Adult exposure to tuberculosis appeared to be a risk factor for familial dementia of the Alzheimer type patients. Autoimmune diseases clustered among the non-familial dementia of the Alzheimer type patients, and also among their relatives. Asthma and infertility were also significantly increased among non-familial dementia of the Alzheimer type relatives. The analysis showed that (1) autoimmunity may be important in the sporadic form of Alzheimer disease; (2) it may be possible to confer a decreased risk for Alzheimer disease among relatives when many autoimmune diseases occur in the family; (3) it may be important to assess environmental risk factors for Alzheimer disease separately in patients with familial and sporadic disease; and (4) the efficacy of drug therapies may be dependent on whether the patients have a familial or sporadic form of Alzheimer disease.<\/jats:p>","DOI":"10.1017\/s0317167100049027","type":"journal-article","created":{"date-parts":[[2016,2,17]],"date-time":"2016-02-17T09:29:08Z","timestamp":1455701348000},"page":"112-119","source":"Crossref","is-referenced-by-count":13,"title":["Immunological Associations in Familial and Non-Familial Alzheimer Patients and Their Families"],"prefix":"10.1017","volume":"21","author":[{"given":"M.F.","family":"Frecker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.E.M.","family":"Pryse-Philli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.R.","family":"Strong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2015,9,18]]},"reference":[{"key":"S0317167100049027_bib040","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(79)91914-7"},{"key":"S0317167100049027_bib034","first-page":"57","article-title":"Alzheimer\u2019s disease and the main histocompatibility complex (HLA system). 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