{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T02:08:16Z","timestamp":1793153296218,"version":"4.5.0"},"reference-count":34,"publisher":"Cambridge University Press (CUP)","issue":"02","license":[{"start":{"date-parts":[[2019,3,14]],"date-time":"2019-03-14T00:00:00Z","timestamp":1552521600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Can. J. Aging"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>R\u00c9SUM\u00c9<\/jats:title><jats:p>Cette \u00e9tude a explor\u00e9 l\u2019efficacit\u00e9 de l\u2019entra\u00eenement a\u00e9robie (EA) pour att\u00e9nuer la progression de l\u2019hyperintensit\u00e9 de la mati\u00e8re blanche (HMB) et les diff\u00e9rences li\u00e9es au sexe pour cette intervention. Un essai contr\u00f4l\u00e9 randomis\u00e9 a \u00e9t\u00e9 men\u00e9 pour \u00e9valuer l\u2019effet de l\u2019EA sur la cognition de personnes ayant un d\u00e9ficit cognitif d\u2019origine vasculaire. Les participants ont \u00e9t\u00e9 r\u00e9partis al\u00e9atoirement entre deux groupes : 6 mois d\u2019EA ou soins standards (groupe contr\u00f4le). Dans un sous-groupe de participants, l\u2019imagerie par r\u00e9sonance magn\u00e9tique a \u00e9t\u00e9 utilis\u00e9e pour quantifier le volume affect\u00e9 par la HMB. Un mod\u00e8le d\u2019analyse de la covariance a permis de mettre en \u00e9vidence une interaction sexe x groupe significative (p = 0,03). En effet, les femmes du groupe EA ont d\u00e9montr\u00e9 une plus grande progression de l\u2019hyperintensit\u00e9 de la mati\u00e8re blanche que les femmes du groupe contr\u00f4le (p = 0,05) pendant la dur\u00e9e de cette \u00e9tude (6 mois). Chez les hommes, aucune diff\u00e9rence n\u2019a \u00e9t\u00e9 observ\u00e9e entre les deux groupes (p = 0,31). Dans le groupe EA, les hommes ont montr\u00e9 une progression significativement moindre de la HMB, comparativement aux femmes (p = 0,01) apr\u00e8s 6 mois. Ainsi, les effets de l\u2019EA sur la progression de la HMB pourraient varier selon le sexe, et l\u2019EA pourrait freiner la progression de la HMB chez les hommes, mais non chez les femmes.<\/jats:p>","DOI":"10.1017\/s0714980818000582","type":"journal-article","created":{"date-parts":[[2019,3,14]],"date-time":"2019-03-14T06:19:52Z","timestamp":1552544392000},"page":"236-244","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":23,"title":["The Effect of Aerobic Exercise on White Matter Hyperintensity Progression May Vary by Sex"],"prefix":"10.1017","volume":"38","author":[{"given":"Elizabeth","family":"Dao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy K.","family":"Barha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John 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