{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:36:56Z","timestamp":1785411416082,"version":"3.56.0"},"reference-count":38,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T00:00:00Z","timestamp":1753660800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/100004411","name":"Heart and Stroke Foundation of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Can. J. Aging"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Postprandial hypotension (PPH) is defined as a postprandial decline in systolic blood pressure (SBP) of 20\u00a0mm of Hg. Some have recommended the use of acarbose (an alpha-glucosidase inhibitor) as a potential therapy for PPH based exclusively on studies of older adults with diabetes. Using a randomized placebo-controlled design, 43 older adults (23 women, 20 men, mean age 77.1\u00a0\u00b1\u00a00.9\u00a0years) were recruited from geriatric medicine outpatient clinics in an academic centre. Although the average decrease in SBP during the meal test was significantly attenuated in the acarbose group (standardized\n                    <jats:bold>\n                      <jats:italic>\u03b2<\/jats:italic>\n                    <\/jats:bold>\n                    \u00a0=\u00a00.724\u00a0\u00b1\u00a00.286,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.017), the acarbose group experienced significantly more PPH events (standardized\n                    <jats:bold>\n                      <jats:italic>\u03b2<\/jats:italic>\n                    <\/jats:bold>\n                    \u00a0=\u00a00.593\u00a0\u00b1\u00a00.279,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.040). Although acarbose attenuated the mean decrease in SBP during the meal test, it did not reduce the actual number of PPH events recorded in a general population of older adults.\n                  <\/jats:p>\n                  <jats:p>ClinicalTrials.gov ID NCT01914133.<\/jats:p>","DOI":"10.1017\/s0714980825100056","type":"journal-article","created":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T09:42:49Z","timestamp":1753695769000},"page":"370-376","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["The Effects of Acarbose on the Postprandial Hypotensive Response in Older Adults"],"prefix":"10.1017","volume":"44","author":[{"given":"Kenneth Micheal","family":"Madden","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03rmrcq20","id-type":"ROR","asserted-by":"publisher"}],"name":"University of British Columbia"},{"id":[{"id":"https:\/\/ror.org\/03rmrcq20","id-type":"ROR","asserted-by":"publisher"}],"name":"University of British Columbia"},{"id":[{"id":"https:\/\/ror.org\/03rmrcq20","id-type":"ROR","asserted-by":"publisher"}],"name":"University of British Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Feldman","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03rmrcq20","id-type":"ROR","asserted-by":"publisher"}],"name":"University of British Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graydon S.","family":"Meneilly","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03rmrcq20","id-type":"ROR","asserted-by":"publisher"}],"name":"University of British Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2025,7,28]]},"reference":[{"key":"S0714980825100056_r24","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/55.9.M535"},{"key":"S0714980825100056_r12","doi-asserted-by":"publisher","DOI":"10.1097\/00126097-200302000-00006"},{"key":"S0714980825100056_r23","first-page":"131","article-title":"Clinical efficacy of jinlida granule in the treatment of postprandial hypotension in elderly diabetic patients","volume":"12","author":"Peng","year":"2018","journal-title":"Chinese Journal of Modern Drug Application"},{"key":"S0714980825100056_r35","doi-asserted-by":"publisher","DOI":"10.1042\/CS20060091"},{"key":"S0714980825100056_r17","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13633"},{"key":"S0714980825100056_r10","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2005.05.019"},{"key":"S0714980825100056_r27","doi-asserted-by":"publisher","DOI":"10.1016\/0895-7061(94)00000-2"},{"key":"S0714980825100056_r36","volume-title":"Study on the mechanism and drug intervention of postprandial hypotension in elderly diabetic patients","author":"Zhang","year":"2014"},{"key":"S0714980825100056_r31","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-015-3638-0"},{"key":"S0714980825100056_r13","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(98)00067-4"},{"key":"S0714980825100056_r18","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(86)90359-0"},{"key":"S0714980825100056_r38","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.1992.tb01754.x"},{"key":"S0714980825100056_r2","first-page":"E459","article-title":"Changes in arterial blood pressure and heart rate induced by glucagon-like peptide-1-(7-36) amide in rats","volume":"266","author":"Barragan","year":"1994","journal-title":"The American Journal of Physiology"},{"key":"S0714980825100056_r21","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-004-0220-0"},{"key":"S0714980825100056_r14","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1995.00430090087010"},{"key":"S0714980825100056_r3","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.8.1870"},{"key":"S0714980825100056_r4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijchy.2020.100071"},{"key":"S0714980825100056_r20","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.13503"},{"key":"S0714980825100056_r1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1997.tb05965.x"},{"key":"S0714980825100056_r5","volume-title":"Statistics: An introduction using R","author":"Crawley","year":"2011"},{"key":"S0714980825100056_r8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.53415.x"},{"key":"S0714980825100056_r28","doi-asserted-by":"publisher","DOI":"10.1016\/S1056-8727(01)00138-6"},{"key":"S0714980825100056_r32","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.056580"},{"key":"S0714980825100056_r9","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-012-6660-x"},{"key":"S0714980825100056_r30","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-2475"},{"key":"S0714980825100056_r19","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-020-00671-8"},{"key":"S0714980825100056_r29","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.091355"},{"key":"S0714980825100056_r6","doi-asserted-by":"publisher","DOI":"10.1007\/BF00237509"},{"key":"S0714980825100056_r11","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-006-3187-y"},{"key":"S0714980825100056_r34","doi-asserted-by":"publisher","DOI":"10.1111\/j.1444-0903.2004.t01-15-.x"},{"key":"S0714980825100056_r26","unstructured":"R Core Team. (2021). R: A language and environment for statistical computing. R Foundation for Statistical Computing. https:\/\/www.R-project.org\/"},{"key":"S0714980825100056_r7","first-page":"441","article-title":"Role of intestinal chemoreception in the induction of gastrointestinal sensations","volume":"105","author":"Feinle","year":"1998","journal-title":"Deutsche Tierarztliche Wochenschrift"},{"key":"S0714980825100056_r15","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-122-4-199502150-00009"},{"key":"S0714980825100056_r16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.1990.tb02268.x"},{"key":"S0714980825100056_r22","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2001.013442"},{"key":"S0714980825100056_r37","doi-asserted-by":"publisher","DOI":"10.1136\/jim-2016-000295"},{"key":"S0714980825100056_r33","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.663635"},{"key":"S0714980825100056_r25","doi-asserted-by":"publisher","DOI":"10.1097\/MBP.0000000000000160"}],"container-title":["Canadian Journal on Aging \/ La Revue canadienne du vieillissement"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0714980825100056","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T10:59:29Z","timestamp":1772794769000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0714980825100056\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,28]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S0714980825100056"],"URL":"https:\/\/doi.org\/10.1017\/s0714980825100056","relation":{},"ISSN":["0714-9808","1710-1107"],"issn-type":[{"value":"0714-9808","type":"print"},{"value":"1710-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,28]]},"assertion":[{"value":"\u00a9 The Author(s), 2025. Published by Cambridge University Press on behalf of The Canadian Association on Gerontology","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives licence (http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0), which permits non-commercial re-use, distribution, and reproduction in any medium, provided that no alterations are made and the original article is properly cited. The written permission of Cambridge University Press must be obtained prior to any commercial use and\/or adaptation of the article.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}