{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T10:26:39Z","timestamp":1648722399630},"reference-count":25,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2015,9,18]],"date-time":"2015-09-18T00:00:00Z","timestamp":1442534400000},"content-version":"unspecified","delay-in-days":7596,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Acta Neuropsychiatr."],"published-print":{"date-parts":[[1994,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>After a description of the harmful effects of psychotropic drugs as well as of the moments of vulnerability to any teratogenic effect, this paper reviews prospective, retrospective and epidemiological studies of the teratogenic effects of anticonvulsants (phenytoin, valproic acid, carbamazepine and barbiturates), lithium, anti-psychotics, benzodiazepines and anti-depressive agents. It is found that the results of these studies are not unequivocal. Only lithium and valproic acid are shown to be teratogenic. In cases where malformations of the fetus are observed, the treatment often consisted in a combination of various psychotropic drugs.<\/jats:p><jats:p>The review is completed with data on the psychopharmacological problems during delivery and their side-effects on the newborn.<\/jats:p>","DOI":"10.1017\/s0924270800034128","type":"journal-article","created":{"date-parts":[[2016,7,26]],"date-time":"2016-07-26T05:12:59Z","timestamp":1469509979000},"page":"77-85","update-policy":"http:\/\/dx.doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Congenital malformations caused by psychotropic drugs in pregnancy"],"prefix":"10.1017","volume":"4","author":[{"given":"G.","family":"de Cuypere","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ph.","family":"Rombaut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"van Moffaert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2015,9,18]]},"reference":[{"key":"S0924270800034128_ref025","first-page":"336","article-title":"Exposure to prescribed drugs in pregnancy and association with congenital malformations","volume":"58","author":"Bracken","year":"1981","journal-title":"Obstet Gynecol"},{"key":"S0924270800034128_ref024","doi-asserted-by":"crossref","first-page":"768","DOI":"10.5694\/j.1326-5377.1973.tb110672.x","article-title":"Tricyclic antidepressants and limb reduction deformitites","volume":"1","year":"1973","journal-title":"Med J Austr"},{"key":"S0924270800034128_ref012","first-page":"410","article-title":"Lithium treatment during pregnancy, delivery and lactation: an update","volume":"51","author":"Schou","year":"1990","journal-title":"J clin Psychiat"},{"key":"S0924270800034128_ref011","first-page":"2103","article-title":"Lithium en zwangerschap: aanbevo-len richtlijnen","volume":"128","author":"Haaften","year":"1984","journal-title":"Ned Tijdschr Geneeskd"},{"key":"S0924270800034128_ref016","doi-asserted-by":"publisher","DOI":"10.1016\/0010-440X(84)90019-1"},{"key":"S0924270800034128_ref008","first-page":"275","volume-title":"Epilepsy, Pregnancy and the Child","author":"Lindhout","year":"1982"},{"key":"S0924270800034128_ref002","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(12)62060-6"},{"key":"S0924270800034128_ref006","first-page":"52","article-title":"Gebruik van valpro'inezuur gedurende de zwangerschap: een indicatie voor prenataal onderzoek op spina bifida","volume":"128","author":"Lindhout","year":"1984","journal-title":"Ned Tijdsch Geneesk"},{"key":"S0924270800034128_ref001","first-page":"145","article-title":"Effets nocifs des drogues sur le d\u00e9veloppement du foetus et son adaptation n\u00e9o-natale","volume":"92","author":"Billeaud","year":"1985","journal-title":"M\u00e9d inf"},{"key":"S0924270800034128_ref023","first-page":"658","article-title":"Limb deformities associated with iminodibenzyl hydrochloride","volume":"59","author":"Morrow","year":"1972","journal-title":"Med J Austr"},{"key":"S0924270800034128_ref017","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1975.03240130020015"},{"key":"S0924270800034128_ref003","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198502283120906"},{"key":"S0924270800034128_ref014","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420150108"},{"key":"S0924270800034128_ref005","first-page":"2012","article-title":"Het verband tussen het gebruik van anti-epileptica door de zwangere vrouw en het ontstaan van aangeboren afwijkingen bij haar kind","volume":"127","author":"Meinardi","year":"1983","journal-title":"Ned Tijdsch Geneesk"},{"key":"S0924270800034128_ref004","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(75)80604-4"},{"key":"S0924270800034128_ref009","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5748.523"},{"key":"S0924270800034128_ref010","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-011-7197-7_48"},{"key":"S0924270800034128_ref013","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(77)90029-1"},{"key":"S0924270800034128_ref015","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1960.03590120014002"},{"key":"S0924270800034128_ref007","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1987.tb05775.x"},{"key":"S0924270800034128_ref020","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198311243092103"},{"key":"S0924270800034128_ref018","first-page":"531","article-title":"Teratogenicity of psychotherapeutic medications","volume":"23","author":"Elia","year":"1987","journal-title":"Psychopharmacol Bull"},{"key":"S0924270800034128_ref019","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(75)92153-4"},{"key":"S0924270800034128_ref021","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197412122912402"},{"key":"S0924270800034128_ref022","first-page":"14","volume":"5","author":"Drug","year":"1975","journal-title":"Bulletin: Teratogenicity of minor tranquillizers"}],"container-title":["Acta Neuropsychiatrica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0924270800034128","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T09:03:39Z","timestamp":1600938219000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0924270800034128\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,12]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1992,12]]}},"alternative-id":["S0924270800034128"],"URL":"https:\/\/doi.org\/10.1017\/s0924270800034128","relation":{},"ISSN":["0924-2708","1601-5215"],"issn-type":[{"value":"0924-2708","type":"print"},{"value":"1601-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,12]]},"assertion":[{"value":"Copyright \u00a9 Scandinavian College of Neuropsychopharmacology 1994","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}