{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T22:14:04Z","timestamp":1758924844030},"reference-count":16,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T00:00:00Z","timestamp":1242345600000},"content-version":"unspecified","delay-in-days":6923,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[1990,6]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>A population of 488 HBsAg carrier individuals, from central Italy, classified on the basis of biochemical, clinical and histological parameters, was analysed for the presence of HBV-DNA in serum and its relationship with HBeAg\/anti-HBe markers. The prevalence of HBV-DNA was 32\u00b78% in chronic patients with biopsy-proven liver disease, and 20 and 4\u00b73% respectively in asymptomatic carriers with and without altered ALT levels. The values in chronic patients were correlated with the histological activity.<\/jats:p><jats:p>Concordance of HBV-DNA presence and HBeAg positivity was observed in only 61\u00b74% of cases. However HBV-DNA prevalence in sera of anti-HBe positive individuals was very low in asymptomatic carriers with normal ALT levels (2\u00b75%). Higher values were observed in anti-HBe positive chronic patients (15\u00b78%) and in carriers occasionally found with changes in ALT without any other clinical sign of illness (16\u00b77%). These data would indicate that HBV-DNA is the serological marker which is most closely related to liver disease.<\/jats:p>","DOI":"10.1017\/s0950268800047518","type":"journal-article","created":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T09:21:47Z","timestamp":1242379307000},"page":"511-518","update-policy":"http:\/\/dx.doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":6,"title":["HBV-DNA, HBeAg\/anti-HBe serological status in hepatitis B chronic individuals from central Italy"],"prefix":"10.1017","volume":"104","author":[{"given":"M.","family":"Rapicetta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Di 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