{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T20:35:26Z","timestamp":1761510926438},"reference-count":11,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T00:00:00Z","timestamp":1242345600000},"content-version":"unspecified","delay-in-days":6862,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[1990,8]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>From 1979 to August 1987, there have been 178 cases of meningococcal disease in Iquique, Chile, a city of about 140000. The attack rate for the last 5 years has been in excess of 20\/100000 per year, more than 20 times greater than for the country overall. The mortality rate was 6%. The disease occurred in patients with ages from 4 months to 60 years, but 89% of cases were in patients &lt;21 years. The largest number of cases were in the age group 5\u20139 years (<jats:italic>n<\/jats:italic>= 54), but the highest incidence occurred in children less than 1 year of age (72\u00b78\/100000 per year). The male\/female ratio was 1\u00b72. Cases occurred all year round with little seasonal variation. Of the 178 cases, 173 were biologically confirmed. Serogroup analysis of strains from 135 patients revealed A = 1, B = 124, C = 10. Forty-four group B strains from 1985\u20137 were serotyped: 15:P1.3 = 36, 15:NT = 4, 4:P1.3 = 2, NT:NT = 2. Ten of 11 of the outbreak strains tested were sulfadiazine-resistant. This is the first recognized outbreak caused by a Gp B:15 strain in South America. It shares many of the characteristics of outbreaks caused by closely related strains in Europe, such as a predilection for older children and adolescents, sulfadiazine-resistance, and sustained high attack rates. The Iquique strain (B:15:P1.3) belongs to the same genetic clone (ET-5 complex) as the Norway (B:15:P1.16) and the Cuban (B:4:P1.15) strains.<\/jats:p>","DOI":"10.1017\/s0950268800047713","type":"journal-article","created":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T09:19:12Z","timestamp":1242379152000},"page":"119-126","update-policy":"http:\/\/dx.doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":41,"title":["Serotype-specific outbreak of group B meningococcal disease in Iquique, 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