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Details of 61 cases are presented.<\/jats:p><jats:p>Of acute cases 80 % had respiratory involvement; at least 63 % had pneumonias. The incidence (22%) of neurological complications was of particular interest; 40% of these patients had prolonged sequelae. One acutely ill patient died of fulminating hepatitis. Patients with pre-existing pathology or immunosuppression were especially susceptible to<jats:italic>C. burnetii<\/jats:italic>.<\/jats:p><jats:p>In the absence of acute sera, the complement fixation test alone provided inadequate differentiation between recent and past Q fever: phase II titres persisted at \u22dd 80 for more than 1 year after the acute infection in 15 cases; maximum duration of persistence was 14 years. Three patients acquired high phase I titres.<\/jats:p><jats:p>Only 5% of cases had chronic Q fever, but in view of the diverse sequelae observed in this series, we suggest that long-term serological and clinical follow-up of all cases of Q fever is fully justified.<\/jats:p>","DOI":"10.1017\/s095026880004797x","type":"journal-article","created":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T09:17:54Z","timestamp":1242379074000},"page":"391-408","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":41,"title":["Q fever in Plymouth, 1972\u201388: A review with particular reference to neurological manifestations"],"prefix":"10.1017","volume":"105","author":[{"given":"S.","family":"Reilly","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. L.","family":"Northwood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. 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