{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T13:25:47Z","timestamp":1762176347521},"reference-count":25,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T00:00:00Z","timestamp":1242345600000},"content-version":"unspecified","delay-in-days":6619,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[1991,4]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Plasmids in five strains of<jats:italic>Salmonella typhimurium<\/jats:italic>resistant to ampicillin, chloramphenicol, gentamicin, neomycin\/kanamycin, streptomycin, sulphonamides, tetracyclines and trimethoprim (ACGKSSuTTm), CGKSSuTTm, ACSSuT or CSSuT which had been isolated from poultry in the first 3 months of 1989 have been characterized and compared with plasmids in two strains of R-types ACGKSSuTTm and ASSuTTm isolated from two patients later in the year. With the exception of the human isolate of R-type ASSuTTm, all strains carried two non-conjugative plasmids, one coding for SSu and belonging to incompatibility group Q, and a second coding for multiple resistance and belonging to the F<jats:sub>I<\/jats:sub><jats:italic>me<\/jats:italic>incompatibility group. The human isolate of R-type ASSuTTm did not carry the<jats:italic>Inc<\/jats:italic>Q, SSu plasmid but like the poultry isolates, carried a non-conjugative F<jats:sub>I<\/jats:sub><jats:italic>me<\/jats:italic>plasmid.<\/jats:p><jats:p>Restriction endonuclease digestion with the enzymes<jats:italic>Eco<\/jats:italic>R I,<jats:italic>Pst<\/jats:italic>I and<jats:italic>Hind<\/jats:italic>III demonstrated that the F<jats:sub>I<\/jats:sub><jats:italic>me<\/jats:italic>plasmids from strains of different R-types showed a high degree of homology but exhibited numerous fragment size polymorphisms. The restriction digest fingerprint of plasmids in the human isolate of R-type ACGKSSuTTm was indistinguishable from a poultry isolate of the same R-type. Analysis of segregants of one of the poultry isolates of R-type ACGKSSuTTm demonstrated that resistance determinants could be rapidly lost from the F<jats:sub>I<\/jats:sub><jats:italic>me<\/jats:italic>plasmid to give rise to a number of R-types and fingerprint patterns. Loss of tetracycline resistance from this plasmid appeared to be correlated with the integration of other plasmid-mediated resistances into the bacterial chromosome. Evidence is presented for the rapid loss of antimicrobial resistance determinants from a multiple resistance plasmid of the F<jats:sub>I<\/jats:sub><jats:italic>me<\/jats:italic>incompatibility group in response to withdrawal of antibiotic selective pressure.<\/jats:p>","DOI":"10.1017\/s0950268800048391","type":"journal-article","created":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T09:13:27Z","timestamp":1242378807000},"page":"247-257","update-policy":"http:\/\/dx.doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":12,"title":["Instability of multiple drug resistance plasmids in<i>Salmonella typhimurium<\/i>isolated from poultry"],"prefix":"10.1017","volume":"106","author":[{"given":"D. J.","family":"Brown","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. 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