{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T06:34:54Z","timestamp":1782455694409,"version":"3.54.5"},"reference-count":13,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T00:00:00Z","timestamp":1242345600000},"content-version":"unspecified","delay-in-days":6619,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[1991,4]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>It had already been shown with a single virulent strain (A42) of <jats:italic>Fusobacterium necrophorum<\/jats:italic> that suspension of the fusobacteria in sub-lethal doses of broth cultures of other bacteria reduced the minimum infective dose (&gt; 10<jats:sup>6<\/jats:sup> organisms) for mice by subcutaneous inoculation, sometimes to &lt; 10 organisms. The present study extended the known range of bacteria with strong infectivity-enhancing properties to include <jats:italic>Bacillus cereus<\/jats:italic>, <jats:italic>Klebsiella oxytoca<\/jats:italic> and <jats:italic>Staphylococcus aureus<\/jats:italic>; and of those with weaker effect to include <jats:italic>Bacillus subtilis<\/jats:italic>, \u2018<jats:italic>Bacteroides melaninogenicus<\/jats:italic>\u2019, <jats:italic>Clostridium sporogenes<\/jats:italic>, <jats:italic>Pasteurella haemolytica<\/jats:italic>, and <jats:italic>Proteus mirabilis<\/jats:italic>.<\/jats:p><jats:p>The study also showed that five further virulent strains of <jats:italic>F. necrophorum<\/jats:italic> closely resembled A42 in respect of striking susceptibility to infectivity enhancement by <jats:italic>Escherichia coli<\/jats:italic>, <jats:italic>Actinomyces (Corynebacterium) pyogenes<\/jats:italic> and <jats:italic>S. aureus<\/jats:italic>. One further strain (A6) of <jats:italic>F. necrophorum<\/jats:italic> resembled A42 in respect of strong infectivity enhancement by <jats:italic>A. pyogenes<\/jats:italic>, <jats:italic>S. aureus<\/jats:italic>, <jats:italic>B. cereus<\/jats:italic> and <jats:italic>K. oxytoca<\/jats:italic> but differed from it and the other five strains in being only slightly affected by <jats:italic>E. coli<\/jats:italic>.<\/jats:p><jats:p>This work was a necessary prelude to the development of a method, based on infectivity enhancement, for the detection and isolation of <jats:italic>F. necrophorum<\/jats:italic> present in small numbers in heavily contaminated material such as faeces.<\/jats:p>","DOI":"10.1017\/s0950268800048457","type":"journal-article","created":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T05:13:27Z","timestamp":1242364407000},"page":"305-310","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":24,"title":["Further observations on enhancement of the infectivity of <i>Fusobacterium necrophorum<\/i> by other bacteria"],"prefix":"10.1017","volume":"106","author":[{"given":"G. R.","family":"Smith","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. A.","family":"Barton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. M.","family":"Wallace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2009,5,15]]},"reference":[{"key":"S0950268800048457_ref009","doi-asserted-by":"publisher","DOI":"10.1099\/00222615-11-2-81"},{"key":"S0950268800048457_ref010","first-page":"1115","article-title":"Fusobacterium necrophorum and Bacteroides melaninogenicus as etiologic agents of foot rot in cattle","volume":"36","author":"Berg","year":"1975","journal-title":"Am J Vet Res"},{"key":"S0950268800048457_ref004","doi-asserted-by":"publisher","DOI":"10.1017\/S0022172400062288"},{"key":"S0950268800048457_ref002","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268800048469"},{"key":"S0950268800048457_ref003","doi-asserted-by":"publisher","DOI":"10.1017\/S0022172400064184"},{"key":"S0950268800048457_ref013","article-title":"Fusobacterium necrophorum \u2013 pathogenic organism?","volume":"20","author":"Hofstad","year":"1985","journal-title":"J Med Microbiol"},{"key":"S0950268800048457_ref012","first-page":"37","article-title":"Observations concernant 7 souches appartenant aux esp\u00e8ces Sphaerophorus necrophorus, Sphaerophorus funduliformis, Sphaerophorus pseudonecrophorus","volume":"121","author":"Beerens","year":"1971","journal-title":"Annls Inst Pasteur Lille"},{"key":"S0950268800048457_ref005","doi-asserted-by":"publisher","DOI":"10.1017\/S0022172400065967"},{"key":"S0950268800048457_ref001","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268800030168"},{"key":"S0950268800048457_ref006","doi-asserted-by":"publisher","DOI":"10.1136\/vr.118.25.691"},{"key":"S0950268800048457_ref007","doi-asserted-by":"publisher","DOI":"10.1017\/S095026880003051X"},{"key":"S0950268800048457_ref008","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268800054546"},{"key":"S0950268800048457_ref011","volume-title":"Pathogenic clostridia","author":"Sterne","year":"1975"}],"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268800048457","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,17]],"date-time":"2019-05-17T18:17:05Z","timestamp":1558117025000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268800048457\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,4]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1991,4]]}},"alternative-id":["S0950268800048457"],"URL":"https:\/\/doi.org\/10.1017\/s0950268800048457","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,4]]},"assertion":[{"value":"Cambridge University Press 1991","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}