{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,24]],"date-time":"2025-05-24T08:04:40Z","timestamp":1748073880536},"reference-count":22,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T00:00:00Z","timestamp":1242345600000},"content-version":"unspecified","delay-in-days":6436,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[1991,10]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Rates of acquisition and loss of <jats:italic>Brugia malayi<\/jats:italic> microfilaraemia were estimated using the parasitological data of a cohort of population in Shertallai, South India. The rate of acquisition of microfilaraemia was found to be dependent on age but not gender. The decline in the rate of acquisition of microfilaraemia in adults above 35 years could be due to the development of acquired immunity. The mean reproductive lifespan for the periodic <jats:italic>Brugia malayi<\/jats:italic> adult female worm was estimated to be 34 years and it was independent of host age and gender. The age-specific estimated proportion of population at risk (microfilaria carriers who lost their microfilaria in course of time) of developing lymphoedema approximately mirrored the observed age specific prevalence of lymphoedema in the study-population. On an average, 99% of population at risk developed manifestations of disease. The estimated population at risk of developing disease in different endemic areas is compared and its epidemiological significance is discussed.<\/jats:p>","DOI":"10.1017\/s0950268800049104","type":"journal-article","created":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T05:11:08Z","timestamp":1242364268000},"page":"453-463","update-policy":"http:\/\/dx.doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":2,"title":["The dynamics of microfilaraemia and its relation with development of disease in periodic <i>Brugia malayi<\/i> infection in South India"],"prefix":"10.1017","volume":"107","author":[{"given":"S.","family":"Sabesan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Krishnamoorthy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. 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