{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T01:27:32Z","timestamp":1776821252046,"version":"3.51.2"},"reference-count":30,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T00:00:00Z","timestamp":1242345600000},"content-version":"unspecified","delay-in-days":5947,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[1993,2]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>To determine whether the risk factors for childhood haemolytic uraemic syndrome (HUS) are similar to risk factors previously reported for<jats:italic>Escherichia coli<\/jats:italic>O 157. H7 gastroenteritis, we conducted a case-control study at eight paediatric hospitals in the summer of 1990. Thirty-four consecutive children with HUS were prospectively enrolled; all had diarrhoea and 88% had laboratory evidence of exposure to verotoxin-producing<jats:italic>E. coli<\/jats:italic>(VTEC). The 102 controls were otherwise healthy children with minor acute injuries. Parents of all subjects responded to a questionnaire about each child's exposure to various foods, methods of food preparation, sources of water, travel, and individuals with diarrhoea.<\/jats:p><jats:p>Children with HUS were significantly more likely than controls to have had close contact with an individual with diarrhoea in the 2 weeks before the onset of illness (74 \u03c5. 29%, P &lt; 0.00001; odds ratio 7\u00b70. 95% CI 2.7\u201318.5). The onset of diarrhoea in the contacts occurred a median of 6 days (range, 1\u2212 &gt; 14 days) before the onset of diarrhoea in the HUS patients. Exposure to undercooked ground meat was not significantly more common in the patients with HUS (15 \u03c5. 8%; P=0.05). These data provide evidence consistent with person-to-person transmission of VTEC in a substantial proportion of episodes of childhood HUS.<\/jats:p>","DOI":"10.1017\/s0950268800050627","type":"journal-article","created":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T09:02:28Z","timestamp":1242378148000},"page":"9-16","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":30,"title":["Diarrhoea in close contacts as a risk factor for childhood haemolytic uraemic syndrome"],"prefix":"10.1017","volume":"110","author":[{"given":"P. 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