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Vibriocidal tests with absorbed antisera have shown no evidence of biotype specificity in the killing of bacteria, but they have confirmed the role of the two serotype-specific antigens in immunity to cholera. The same presence of serotype specificity, and absence of biotype specificity, has been found by bacterial agglutination, an easier and quicker serological test. The use of this simpler test in ensuring a balanced serotype response to cholera vaccine is discussed, together with evidence that may lead to the production of more effective vaccine and better immunity.<\/jats:p>","DOI":"10.1017\/s0950268800050913","type":"journal-article","created":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T09:02:03Z","timestamp":1242378123000},"page":"489-497","update-policy":"http:\/\/dx.doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":5,"title":["Corresponding type-specificity of vibriocidal and agglutinating activities of<i>Vibrio cholerae<\/i>antisera: relevance to vaccine immunogenicity"],"prefix":"10.1017","volume":"110","author":[{"given":"N. 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