{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T04:55:49Z","timestamp":1773291349916,"version":"3.50.1"},"reference-count":26,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T00:00:00Z","timestamp":1242345600000},"content-version":"unspecified","delay-in-days":5705,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[1993,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>This study investigated the morbidity associated with respiratory virus infections in patients with well-documented chest disease, and the risk of transmission between close contacts. Patients informed the study team if they were exposed to a family member or colleague with a cold. Patients and symptomatic index cases recorded respiratory symptoms during the study period. Acute nasopharyngeal swabs and paired sera were obtained for viral diagnosis.<\/jats:p><jats:p>Twenty-five (43%) of 58 recorded exposures resulted in a symptomatic illness and 16 (28%) patients developed lower respiratory tract symptoms. Sixteen (64%) of the 25 symptomatic patients contacted their general practitioner, 14 (56%) received antibiotics and 4 (16%) were hospitalized. Mean duration of illness was 10\u00b76 days in symptomatic patients and 5\u00b77 days in their corresponding index cases (P &lt; 0\u00b7005). Mean symptom scores were 100\u00b76 in symptomatic patients and 62.2 in index cases (P &lt; 0\u00b701). Respiratory viruses were identified in 19 (33%) episodes. Rhinovirus, coronavirus and respiratory syncytial virus infections were all associated with lower respiratory tract exacerbations.<\/jats:p><jats:p>Respiratory tract symptoms following exposure to a cold were comparatively severe in these patients with chronic chest disease. This group of patients might gain particular benefit from the introduction of effective vaccines or antiviral therapy.<\/jats:p>","DOI":"10.1017\/s0950268800057046","type":"journal-article","created":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T08:57:14Z","timestamp":1242377834000},"page":"337-346","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":22,"title":["Impact of respiratory virus infection in patients with chronic chest disease"],"prefix":"10.1017","volume":"111","author":[{"given":"M. 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