{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T21:47:26Z","timestamp":1792273646403,"version":"4.4.0"},"reference-count":31,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T00:00:00Z","timestamp":1242345600000},"content-version":"unspecified","delay-in-days":5644,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[1993,12]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    The fact that\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    can revert to a coccoid form has stimulated speculation about its role in transmission and as a possible cause of reinfection in duodenal ulcer disease. Bismuth subcitrate (32 \u03bcg\/ml), bismuth subsalicylate (64 \u03bcg\/ml), amoxicillin (0\u00b705 \u03bcg\/ml) and erythromycin (4 \u03bcg\/ml) inhibited the growth of\n                    <jats:italic>H. pylori<\/jats:italic>\n                    and stimulated the formation the formation of basically respiring but non-culturable coccoid structures. The presence of polyphosphates as energy and phosphorus source permits a certain level of endogenous metabolism to preserve RNA and DNA, as well as structural components like cell wall, cell membrane and cytoplasma for at least 3 months. However, the applied standard laboratory methods were insufficient for regrowth of\n                    <jats:italic>H. pylori<\/jats:italic>\n                    out of the coccoid form.\n                  <\/jats:p>","DOI":"10.1017\/s0950268800057216","type":"journal-article","created":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T04:50:24Z","timestamp":1242363024000},"page":"483-490","source":"Crossref","is-referenced-by-count":175,"title":["The coccoid forms of\n                    <i>Helicobacter pylori<\/i>\n                    . Criteria for their viability"],"prefix":"10.1017","volume":"111","author":[{"given":"G.","family":"Bode","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Mauch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Malfertheiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2009,5,15]]},"reference":[{"key":"S0950268800057216_ref031","doi-asserted-by":"publisher","DOI":"10.1099\/00222615-38-1-6"},{"key":"S0950268800057216_ref030","first-page":"1545","article-title":"Drug therapy for Helicobacter pylori infection: problems and pitfalls","volume":"85","author":"Glupczynski","year":"1990","journal-title":"Am J Gastroenterol"},{"key":"S0950268800057216_ref029","doi-asserted-by":"publisher","DOI":"10.1139\/m88-076"},{"key":"S0950268800057216_ref027","first-page":"115","article-title":"Effects of acquatic environmental stress on enteric bacterial pathogens","volume":"70","author":"McFeters","year":"1991","journal-title":"J Appl Bacteriol"},{"key":"S0950268800057216_ref025","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1128\/AEM.55.2.495-499.1989","article-title":"In situ survival of Vibrio cholerae and Escherichia coli in a tropical rain forest watershed","volume":"55","author":"Perez-Rosas","year":"1989","journal-title":"Appl Environ Microbiol"},{"key":"S0950268800057216_ref023","doi-asserted-by":"publisher","DOI":"10.1139\/m84-049"},{"key":"S0950268800057216_ref010","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1128\/AEM.57.3.875-878.1991","article-title":"Viable but nonculturable bacteria in drinking water","volume":"57","author":"Byrd","year":"1991","journal-title":"Appl Environ Microbiol"},{"key":"S0950268800057216_ref013","first-page":"99","volume-title":"Principles and techniques of electron microscopy","volume":"2","author":"Haschemeyer","year":"1972"},{"key":"S0950268800057216_ref014","doi-asserted-by":"publisher","DOI":"10.1016\/S0580-9517(08)70050-3"},{"key":"S0950268800057216_ref001","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.42.7.778-a"},{"key":"S0950268800057216_ref028","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2911(08)60385-9"},{"key":"S0950268800057216_ref011","doi-asserted-by":"publisher","DOI":"10.1017\/S095026880004930X"},{"key":"S0950268800057216_ref002","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-75726-6_17"},{"key":"S0950268800057216_ref016","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-75315-2_5"},{"key":"S0950268800057216_ref005","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)92894-L"},{"key":"S0950268800057216_ref020","first-page":"81","article-title":"Helicobacter pylori, musings from the epidemiologic armchair","volume":"109","author":"Koster","year":"1992","journal-title":"Epidemiol Infect"},{"key":"S0950268800057216_ref021","first-page":"179","article-title":"Polymorphism in Helicobacter pylori \u2013 a key function for recurrent infection ?","volume":"87","author":"Bode","year":"1992","journal-title":"Med Klin"},{"key":"S0950268800057216_ref008","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.mi.41.100187.000325"},{"key":"S0950268800057216_ref018","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199002083220603"},{"key":"S0950268800057216_ref007","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(93)90839-5"},{"key":"S0950268800057216_ref004","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)93196-G"},{"key":"S0950268800057216_ref003","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.43.7.609-b"},{"key":"S0950268800057216_ref026","doi-asserted-by":"crossref","first-page":"3388","DOI":"10.1128\/AEM.57.11.3388-3389.1991","article-title":"Recovery of injured Campylobacter jejuni cells after animal passage","volume":"57","author":"Saha","year":"1991","journal-title":"Appl Environ Microbiol"},{"key":"S0950268800057216_ref024","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1128\/AEM.52.3.531-538.1986","article-title":"Viable but nonculturable stage of Campylobacter jejuni and its role in survival in the natural aquatic environment","volume":"52","author":"Rollins","year":"1986","journal-title":"Appl Environ Microbiol"},{"key":"S0950268800057216_ref006","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1128\/IAI.60.2.606-611.1992","article-title":"Helicobacter mustelae isolation from feces of ferrets: evidence to support fecal\u2013oral transmission of a gastric Helicobacter","volume":"60","author":"Fox","year":"1992","journal-title":"Infect Immun"},{"key":"S0950268800057216_ref009","doi-asserted-by":"publisher","DOI":"10.1007\/BF00397156"},{"key":"S0950268800057216_ref022","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1128\/JB.164.1.338-343.1985","article-title":"Morphological forms and viability of Campylobacter species studied by electron microscopy","volume":"164","author":"Ng","year":"1985","journal-title":"J Bacteriol"},{"key":"S0950268800057216_ref012","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.6078.9"},{"key":"S0950268800057216_ref015","unstructured":"15. Bode G , Mauch F , Ditschuneit H , Malfertheiner P . Identification and characterization of polyphosphates in Helicobacter pylori. In press."},{"key":"S0950268800057216_ref017","first-page":"35","article-title":"Coccoid forms of Helicobacter pylori are viable","volume":"23","author":"Bode","year":"1991","journal-title":"Ital J Gastroenterol"},{"key":"S0950268800057216_ref019","doi-asserted-by":"publisher","DOI":"10.1017\/S095026880004872X"}],"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0950268800057216","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T01:04:18Z","timestamp":1589763858000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0950268800057216\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,12]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1993,12]]}},"alternative-id":["S0950268800057216"],"URL":"https:\/\/doi.org\/10.1017\/s0950268800057216","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,12]]}}}